Salubris Biotherapeutics · 6 hours ago
Senior Director/Vice President, Preclinical Pharmacology
Gaithersburg, MD
Full-time
Onsite
Director/Executive
10+ years expSalubris Biotherapeutics is a clinical-stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics. They are seeking a Senior Director or Vice President of Preclinical Pharmacology to lead the integration of in vivo pharmacology and toxicology into R&D strategy, guiding programs from late research through IND submissions.
BiotechnologyHealthcarePharmaceuticalHealth Care
Hiring Manager
Alida Simon
Responsibilities
Preclinical Pharmacology Oversight: Leverage disease biology knowledge to design, manage, and interpret pharmacology and PK/PD studies, and guide and oversee toxicology studies (GLP/non-GLP), to enable development candidate nomination and IND application. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages
Cross-Functional Integration: Lead cross-functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans
Strategic Program Leadership: Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategies across the portfolio and drive new discovery initiatives grounded in scientific rigor and corporate strategy
Qualification
Required
PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline
10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical drug discovery and/or pharmacology
Demonstrated ability as program lead to advance programs from lead optimization to IND approval; preference for experience with complex biologics, such as antibodies (multispecific, antibody-protein fusions), and/or antibody conjugates (antibody-drug conjugates with small molecule payloads such as cytotoxic agents, toxins or others, antibody-oligonucleotide conjugates such as antisense oligos, siRNAs)
Deep expertise in cardiovascular and/or metabolic disease biology, with working experience designing and interpreting disease-relevant in vivo models
Solid working knowledge in bioanalysis, PK/PD, and DMPK. Sufficient understanding of toxicology principles to provide scientific oversight of GLP and non-GLP toxicology studies conducted at CROs
Experience delivering high-quality preclinical/nonclinical data packages for development candidate selection and IND application. Familiarity with FDA/EMA expectations for nonclinical data packages supporting biologics development
Strong strategic thinking and scientific judgment with excellent problem-solving capabilities
Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences
Strong interpersonal skills with the ability to motivate, influence, and lead cross-functional teams in a matrixed environment
Demonstrated ability to work collaboratively and influence at all levels of the organization
Independent, self-motivated leader with the ability to work in a fast-paced, team-based drug discovery and development environment
Preferred
Experience across oncology and CVM therapeutic areas is a strong plus
Benefits
Competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits
Company
Salubris Biotherapeutics
SalubrisBio was founded in August 2016 as a subsidiary of the China-based pharmaceutical company Salubris Pharmaceuticals Co. Ltd. (www.salubris.com).
11-50 employees
H1B Sponsorship
Salubris Biotherapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2021 (1)
Funding
Current Stage
Early StageTotal Funding
$102MKey Investors
Shenzhen Salubris Pharmaceuticals
2024-04-22Series A· $35M
2023-03-28Corporate Round· $35M
2022-03-07Corporate Round· $32M
Leadership Team
Samuel Murphy
Chief Executive Officer
Jijun Dong
Chief Scientific Officer
Recent News
2025-10-18
2025-05-04
Company data provided by crunchbase