Neurocrine Biosciences · 23 hours ago
Scientist / Senior Scientist, Bioanalysis - Ligand Binding Assays
San Diego, CA
Full-time
Onsite
Mid, Senior Level
$111K/yr - $151K/yr
2+ years expNeurocrine Biosciences is a leading neuroscience-focused biopharmaceutical company dedicated to developing life-changing treatments for neurological disorders. The role involves developing and optimizing ligand binding assays for preclinical pharmacokinetic studies and collaborating with various teams to ensure data integrity and quality.
BiotechnologyHealthcarePharmaceuticalHealth Care
Responsibilities
Develop, optimize, and qualify ligand binding assays (e.g., ELISA, MSD/ECL, Gyrolab) to support preclinical non-regulated PK studies of antibodies, bispecifics, and fusion proteins in rodents and monkeys
Perform hands-on bioanalysis of preclinical samples and ensure data quality, integrity, and scientific rigor
Author and review bioanalytical protocols, assay qualification/validation reports, and preclinical study reports
Analyze, interpret, and clearly communicate PK bioanalytical data to project and DMPK teams
Collaborate closely with DMPK, toxicology, and pharmacology groups to support study design and data interpretation
Interact with external CROs, including:
Supporting assay and method transfer
Providing technical oversight during outsourced studies
Reviewing CRO data, reports, and study documentation
Troubleshoot assay issues and continuously improve assay performance and workflows
ADA assay development and support (screening/confirmatory/titer) may be involved on selected programs and is considered a desirable add-on to the primary PK role
At the Senior Scientist level: provide technical leadership, mentor junior scientists, and contribute to preclinical bioanalytical and outsourcing strategy
Qualification
Required
BS/BA degree with 2+ years of industry experience in bioanalysis OR
MS/MA degree and some experience as noted above OR
PhD or equivalent and some experience as noted above
Hands-on experience with ligand binding assay development for PK bioanalysis
Experience supporting preclinical non-regulated studies, preferably in rodents and/or non-human primates
Basic understanding of GLP principles and bioanalytical best practices
Strong experimental, data analysis, and documentation skills
BS/BA degree with 5+ years of industry experience in bioanalysis OR
MS/MA degree and 3+ years of experience as noted above OR
PhD or equivalent and some experience as noted above
Demonstrated expertise in preclinical PK LBA strategy and execution
Experience supporting GLP toxicology studies and working with quality/compliance functions
Proven experience interacting with and overseeing external CROs
Ability to work independently, lead bioanalytical efforts, and mentor junior scientists
Preferred
Experience with ADA assay development is desirable and would be considered an add-on to the primary PK-focused responsibilities
ADA assay development and support (screening/confirmatory/titer) may be involved on selected programs and is considered a desirable add-on to the primary PK role
Benefits
Annual bonus with a target of 20% of the earned base salary
Eligibility to participate in our equity based long term incentive program
Retirement savings plan (with company match)
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans
Company
Neurocrine Biosciences
Neurocrine Biosciences engages in the discovery and development of drugs for the treatment of neurological and endocrine-related diseases.
1001-5000 employees
H1B Sponsorship
Neurocrine Biosciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (16)
2024 (9)
2023 (8)
2022 (2)
2021 (5)
2020 (6)
Funding
Current Stage
Public CompanyTotal Funding
$260MKey Investors
Venrock
2015-02-19Post Ipo Equity· $250M
2009-12-17Post Ipo Equity· $10M
1996-05-31IPO
Leadership Team
Matt Abernethy
Chief Financial Officer
D
Dimitri Grigoriadis
VP, Research
Recent News
2026-02-11
Company data provided by crunchbase