Roche · 1 day ago
Principal Scientist/Senior Principal Scientist, Complex In Vitro Systems, Predictive Toxicology
South San Francisco
Full-time
Onsite
Senior Level, Lead/Staff
$142K/yr - $322K/yr
5+ years expRoche, through its member Genentech, is a leader in the biotechnology industry focused on developing innovative therapies for serious diseases. The role involves leading the Lung Modeling team to design and develop advanced in vitro models to enhance drug safety assessments and support lung-focused drug discovery efforts.
BiotechnologyMedical DeviceHealthcarePharmaceuticalHealth CareHealth DiagnosticsOncologyPrecision Medicine
Responsibilities
Develop and implement the strategic roadmap for lung modeling within CiS, ensuring alignment with organizational drug discovery and development objectives
Lead, mentor, and develop a high-performing and motivated team of scientists who collectively design, develop, and characterize advanced lung in vitro models, such as airway and alveolar organoids, air-liquid interface 3D cultures, organ-on-chip, and other microphysiological systems, to address critical questions in lung drug discovery and development. Projects can span from modeling healthy and disease alveolar, small airway, and large airway with and without vascular or stromal components
Provide scientific guidance, teach lab techniques, and ensure professional growth and career development for junior team members with care and commitment
Act as a primary liaison between the CiS team and internal research teams, translational medicine, and drug discovery units at Genentech and Roche to maximize the impact of strategic lab activities across lung-focused projects
Facilitate and manage partnerships with external collaborators, including academic institutions, consortiums, and Contract Research Organizations (CROs) to advance lung modeling capabilities
Share your research in the form of peer-reviewed papers and presentations in cross-functional forums, internal meetings, and external conferences to communicate platform capabilities, progress, and outcomes related to lung modeling
Qualification
Required
Ph.D. in biology, bioengineering, biomedical engineering, pharmacology, chemical engineering, or a related field, with significant experience in in vitro systems, specifically lung modeling. Exceptional candidates with equivalent experience will be considered
For Principal Scientist (5+ years) and for Senior Principal Scientist (9+ years) years of experience in pharmaceutical, biotechnology, academia, or research organizations, with a strong focus on complex in vitro lung systems
Proven expertise in developing, qualifying, and applying 3D lung tissue models, organoids, microphysiological systems (MPS), or related platforms in a drug discovery or translational research setting
Toxicology experience is a plus, with a focus on leveraging CIVMs to elucidate mechanisms of toxicity and predict safety
Demonstrated scientific leadership, including leading projects, setting strategic direction, and potentially managing small teams
Track record of significant scientific contributions through peer-reviewed publications and presentations in areas related to complex in vitro lung systems
Experience in managerial/mentorship roles is highly desirable
Prior strategy-focused or program management roles are a plus
An existing external network and presence in the complex in vitro modeling space, particularly concerning lung models, is preferred
Preferred
Deep understanding of lung biology and the underlying mechanisms of lung diseases, coupled with profound knowledge of how complex in vitro systems can be applied in lung disease and healthy tissue modeling
Hands-on expertise with cells of pulmonary origin or iPSC-derived lung cell cultures. Experience with 3D co-cultures and 3D vasculature are a plus
Proficiency with various cellular assays and readouts relevant to lung function and toxicity; excellent light microscopy skills are a plus
Exceptional strategic thinking with the ability to define a clear vision for lung modeling and execute effectively
Outstanding communication and influencing skills, with a proven ability to engage deeply with both scientific and leadership audiences
Highly collaborative spirit, professionalism, and a demonstrated ability to forge successful collaborations across diverse functions
Excellent organizational and management skills coupled with the ability to effectively prioritize multiple complex projects
Benefits
A discretionary annual bonus may be available based on individual and Company performance.
Relocation benefits are available for this position for those that qualify.
Company
Roche
Roche is a pharmaceutical and diagnostics company that offers medicines and diagnostic tests for various medical conditions and diseases.
10001+ employees
H1B Sponsorship
Roche has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (9)
2023 (6)
2022 (2)
2021 (2)
Funding
Current Stage
Public CompanyTotal Funding
$7.79BKey Investors
SoftBankSCALE AINovartis
2021-08-04Post Ipo Equity· $5B
2020-12-07IPO
2020-05-06Post Ipo Equity· $0.5M
Leadership Team
Alan Hippe
Member of the Executive Board - Group CFO
Christine Bakan
Global Head and Group Vice President, Computational Science and Informatics R&D
Recent News
2026-02-08
2026-02-07
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