Bristol Myers Squibb · 11 hours ago
Senior Manager, Principal Software Engineer, Clinical Pharmacology and Pharmacometrics
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$165K/yr - $200K/yr
7+ years expBristol Myers Squibb is a leading biopharmaceutical company that focuses on innovative work that transforms the lives of patients. The Principal Software Engineer will lead the design, development, and deployment of software and data platforms supporting Clinical Pharmacology & Pharmacometrics, working closely with computational scientists and IT teams to enhance drug development and translational science.
BiotechnologyMedical DeviceHealthcarePharmaceuticalHealth CareMedicalPrecision Medicine
Responsibilities
Support deployment and operation of AI/ML models, simulation tools, and dashboards for scientific users
Lead the integration of HPC, cloud, and Kubernetes-based compute environments; optimize parallelization and resource utilization
Collaborate with domain scientists, IT, and other stakeholders to gather requirements and translate scientific workflows into robust technical solutions
Drive continuous improvement through automation, system upgrades, and stakeholder feedback
Manage platform security, validation, and compliance in coordination with IT and cybersecurity teams
Architect, develop, and maintain scalable software systems and data platforms for clinical pharmacology and pharmacometrics use cases
Mentor engineers and contribute to best practices (CI/CD, Agile)
Troubleshoot, monitor, and optimize performance of deployed systems
Qualification
Required
BS/MS/PhD in Computer Science, Software Engineering, or related field; higher degrees preferred
7+ years hands-on experience in software engineering, ideally in life sciences or healthcare domains
Proven track record architecting and delivering production-grade software and data platforms (preferably supporting scientific research, modeling or analytics)
Experience in cross-functional collaboration in matrixed, stakeholder-driven environments
Developer with programming skills in Python (primary) and R, integrating with API endpoints in AWS or Google cloud, knowledge of markdown languages such as Quarto/Typst
Demonstrated success building GenAI applications and agentic workflows, including fine-tuning and deploying LLMs. Proven experience working with LLM-based content ingestion, prompt engineering, and automating content generation involving complex tables, images, special characters, headers, footers, and merged columns to produce new reports from diverse source documents
Experience working of cloud services (AWS, Azure, GCP), HPC, Kubernetes, and parallel/distributed computing
Familiarity with software validation, compliance, and best practices in regulated environments
Understand all aspects of software development lifecycle
Understand various SDLC methodologies (Agile, Scrum, Waterfall etc.)
Familiarity with MATLAB, WebAPP
Excellent problem-solving, communication, and stakeholder engagement skills
Preferred
knowledge of vector databases and graph RAG would be a plus
Experience with Posit Workbench/RStudio Server, NAS integration, or similar collaborative scientific platforms
Knowledge of QSP, PBPK, PK/PD modeling or pharmaceutical R&D workflows
Experience implementing robust access controls, NFS, ACLs, and enterprise authentication
Agile and DevOps methodologies, CI/CD, and automation scripting (e.g., Bash, Ansible, CFT, Terraform)
Benefits
Health Coverage Medical, pharmacy, dental, and vision care.
Wellbeing Support Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Paid Time Off
Company
Bristol Myers Squibb
At Bristol Myers Squibb, we work every day to transform patients’ lives through science.
10001+ employees
H1B Sponsorship
Bristol Myers Squibb has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (247)
2024 (278)
2023 (231)
2022 (180)
2021 (181)
2020 (169)
Funding
Current Stage
Public CompanyTotal Funding
$29.33BKey Investors
Venrock
2025-11-05Post Ipo Debt· $5.75B
2024-02-14Post Ipo Debt· $13B
2023-10-30Post Ipo Debt· $4.5B
Leadership Team
Charles Bancroft
CFO
Cristian Massacesi
Executive Vice President, Chief Medical Officer and Head of Development
Recent News
Labiotech UG
2026-02-07
Company data provided by crunchbase