Calico Life Sciences · 1 day ago
Scientist /Senior Scientist, Aging Biology
South San Francisco, CA
Full-time
Onsite
Mid, Senior Level
$156K/yr - $191K/yr
2+ years expCalico is an Alphabet-founded research and development company focused on understanding the biology of human aging. They are seeking a highly motivated Scientist/Senior Scientist in Aging Biology to elucidate the mechanisms of action of therapeutic targets within their aging biology pipeline, translating findings into clinical development.
Biotechnology
Responsibilities
Independently design and lead experimental strategies to elucidate the molecular and cellular mechanisms of action for aging targets and biomarkers, generating insights that guide program direction
Conduct in vitro and ex vivo studies to investigate target biology in key aging-related processes, including stem cell function, tissue repair, and signaling or transcriptional regulation
Compare acute and chronic pathway modulation in tissue injury and aging models to understand how stress responses and repair mechanisms evolve with age
Investigate the molecular drivers of in vivo phenotypes in preclinical aging models to identify biomarkers and translatable mechanisms relevant to clinical development
Collaborate with in vivo pharmacology and biomarker teams to select and leverage preclinical models that best probe target biology
Partner with cross-functional groups (e.g., Biomarkers, Genomics, Protein Sciences) to integrate multi-omic datasets and build a comprehensive mechanistic framework
Analyze, interpret, and present complex data and strategic recommendations to internal project teams and senior leadership
Maintain rigorous experimental documentation and contribute to internal reports, publications, and regulatory submissions
Qualification
Required
Ph.D. in Cell Biology, Molecular Biology, Physiology, or a related field, with 2-5 years (for Scientist level) or 5+ years (for Senior Scientist level) of relevant industry or post-doctoral experience
Demonstrated expertise in designing and executing complex experiments to elucidate mechanisms of action in age-related disease models
Strong hands-on experience with a range of cellular and molecular biology techniques (e.g., primary cell culture, flow cytometry, single-cell RNAseq, qPCR, Western blot, ELISA, functional assays)
Proven ability to think critically and solve complex biological problems
Strong data analysis skills and proficiency with Prism or similar software
Exceptional organizational skills and meticulous attention to detail, with a proven ability to manage complex projects
Strong teamwork and communication skills, with an ability to collaborate effectively in a cross-functional environment
Flexible, able to respond quickly to shifting priorities and to multitask
Must be willing to work onsite five days per week
Preferred
Working knowledge of formulation approaches for various routes of administration, including intravenous (IV), subcutaneous (SC), intraperitoneal (IP), and oral
Familiarity with in vivo models of metabolic or fibrotic disease
Expertise in mesenchymal or hematopoietic stem cell biology, fibrosis, or tissue repair
Experience with R or Python for data integration and visualization
Background in growth factor signaling, extracellular matrix biology, or proteomics
Benefits
Eligible for two annual cash bonuses
Company
Calico Life Sciences
Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.
201-500 employees
H1B Sponsorship
Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (12)
2023 (7)
2022 (10)
2021 (5)
2020 (14)
Funding
Current Stage
Growth StageLeadership Team
Ashley Archuleta
Sr. Administrative Assistant to the Chief Business Officer
Jonathan Lewis
Chief Business Officer
Recent News
2026-02-05
Research & Development World
2026-01-23
2026-01-22
Company data provided by crunchbase