e184 · 1 day ago
Scientist, Cell Biology & Screening
Portland, Oregon Metropolitan Area
Full-time
Onsite
Mid, Senior Levele184 is a biotechnology research company focused on advancing in vitro gametogenesis. The Scientist role involves owning high-throughput screening campaigns, designing experiments, executing them, analyzing results, and collaborating across disciplines to drive discovery.
Biotechnology
Responsibilities
Engineer reporter systems: Design, generate, and validate CRISPR-based reporter lines and develop quantitative cellular assays hands-on to enable robust phenotypic screening readouts
Own screening end-to-end: Design TF screening experiments (pooled and arrayed), construct screening libraries, execute experiments at the bench, and manage sample processing through hit validation
Drive the discovery cycle: Analyze screening data to identify hits, validate candidates through arrayed experiments, characterize mechanisms of action, and design next-iteration screens
Collaborate across disciplines: Partner with bioinformaticians on experimental-computational workflow integration and with biology experts to ensure screening readouts capture biologically meaningful phenotypes
Qualification
Required
PhD in Cell Biology, Molecular Biology, Genetics, Biochemistry, or related field
Hands-on high-throughput screening experience (pooled and/or arrayed) with mammalian cells, including iPSCs
CRISPR/Cas9 genome editing and reporter development expertise
Strong molecular biology foundation (cloning, plasmid design, library construction) and quantitative assay development
Flow cytometry or high-content imaging for cellular analysis
You are reliable, adaptable, and ready to tackle occasional weekend maintenance to keep the science moving
Preferred
Industry R&D experience in biotech or pharmaceutical settings
Track record of end-to-end screening project ownership - from design through execution and validation
Experience with high-throughput automation or liquid handling
Hands-on sequencing experience (scRNA-seq, ATAC-seq) including library prep, plus proficiency with bioinformatics tools
Immunofluorescence microscopy and imaging
Benefits
Comprehensive Medical, Dental, Vision, and 401(k) with company match
20 days PTO + 11 paid holidays
Company
e184
e184 is an Advanced Research Funding Organization (ARFO) that supports frontier science and technology.
Founded in 2023
2-10 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase