Solid Biosciences · 1 day ago
Director, Discovery & Translational Development
Boston, MA
Full-time
Onsite
Director/Executive
$218K/yr - $250K/yr
8+ years expSolid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases. The Director, Discovery & Translational Development will provide scientific and strategic leadership for AAV-based gene therapy programs, ensuring successful advancement from preclinical development through IND and into the clinic.
BiotechnologyGeneticsHealth CareMedical
Responsibilities
Own and drive the translational strategy for neuromuscular gene therapy programs, ensuring alignment between preclinical data, biomarker strategy, and clinical interpretation
Provide scientific leadership for mechanism of action, biodistribution, transgene expression, durability, and functional efficacy across relevant disease models
Define and oversee biomarker frameworks that link nonclinical data to clinical endpoints and regulatory expectations
Establish data standards, success criteria, and decision points to support confident program advancement
Provide scientific oversight and accountability for IND-enabling studies, including study design, CRO execution, data review, and interpretation
Contribute to and review regulatory-facing documents (e.g., study reports, investigator brochures, briefing packages, responses to agency questions)
Partner with Program Management to ensure timelines, risks, and dependencies are clearly defined and proactively managed
Support development and refinement of Target Product Profiles (TPPs) and program risk-mitigation strategies
Serve as a core scientific representative on cross-functional program teams, working closely with Clinical Development, Regulatory Affairs, CMC, Bioanalytics, and Quality
Communicate complex scientific concepts and data clearly to senior leadership and executive audiences, enabling informed decision-making
Represent DTD in internal governance forums and, as appropriate, external scientific or regulatory interactions
Provide scientific mentorship and leadership to scientists within DTD, fostering rigor, accountability, and translational thinking
Guide experimental planning and data interpretation across the team without necessarily being hands-on at the bench
Contribute to building scalable DTD processes, platforms, and best practices
Qualification
Required
PhD in Muscle Biology, Neuroscience, Molecular Biology, Cell Biology, Genetics, Pharmacology, or a related life sciences discipline
8–12+ years of relevant experience, with substantial experience in biotechnology or pharmaceutical industry settings
Direct experience leading or significantly contributing to neuromuscular disease programs, preferably DMD
Demonstrated experience advancing AAV gene therapy programs through preclinical development and IND submission
Deep familiarity with neuromuscular disease models and translational endpoints
Expertise in molecular, histological, and functional assays relevant to gene therapy
Strong data interpretation and critical assessment skills; able to integrate complex datasets across modalities
Experience overseeing CROs and external collaborators
Proven ability to influence across functions and operate effectively in a matrixed organization
Clear, concise scientific communication tailored to diverse audiences
Preferred
Postdoctoral training in neuromuscular disease or gene therapy is preferred
Experience engaging with or supporting regulatory interactions (FDA, EMA) is strongly preferred
Demonstrated leadership in AAV-based gene therapy development, including translational and IND-supporting work
Strong translational mindset with the ability to bridge preclinical data to clinical hypotheses and regulatory strategy
Strategic thinking combined with scientific rigor and attention to detail
Benefits
Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
401(k) program participation with competitive company matched contributions
Eligibility to participate in Solid’s Employee Stock Purchase Plan
Mobile phone subsidy for eligible employees
Tuition Reimbursement
Vision Coverage
Life Insurance
Voluntary Pet Insurance
Employee Discount Program on Travel, Entertainment, and Services
Employee Assistance Programs
Daily Subsidized Lunch Delivery (onsite @ Hood Park)
Free Onsite Full-Service Gym (onsite @ Hood Park)
Employee Parking (onsite @ Hood Park)
12 Observed Holidays and a winter shut down
15-day PTO Policy and a 40-hour rollover YoY
40-hour Sick Policy
8 Hour Floating Holiday
Company
Solid Biosciences
Solid Biosciences is a life science company that conducts research for the treatment of Duchenne muscular dystrophy.
51-200 employees
H1B Sponsorship
Solid Biosciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (6)
2024 (3)
2023 (2)
2022 (4)
2021 (2)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$810.3MKey Investors
Bain Capital Life Sciences,Perceptive Advisors,RA Capital ManagementUltragenyx PharmaceuticalBain Capital Life Sciences,RA Capital Management
2025-02-18Post Ipo Equity· $200M
2024-01-08Post Ipo Equity· $109M
2022-09-30Post Ipo Equity· $75M
Leadership Team
Alexander Cumbo
CEO and President
Kevin Tan
Chief Financial Officer
Recent News
Pharmaceutical Technology
2026-01-16
Company data provided by crunchbase