Johnson & Johnson Innovative Medicine · 22 hours ago
Senior Scientist, Global Proteomics
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
$109K/yr - $175K/yr
3+ years expJohnson & Johnson Innovative Medicine is focused on healthcare innovation to deliver breakthroughs for complex diseases. They are seeking a Senior Scientist in Global Proteomics to lead high-scale proteomic analysis and support drug discovery efforts through innovative mass spectrometry technologies.
Pharmaceuticals
Responsibilities
Joining a team of wet lab scientists enabling proteomic impact across a wide variety of programs and therapeutic modalities
Planning and performing wet lab proteomic activities supporting evaluation of therapeutic candidates and drive SAR enabled risk mitigation of small molecules
Operating and maintaining LC-MS instrumentation (Thermo Orbitrap Exploris/Eclipse/Astral, Bruker timsTOF; LC systems such as Vanquish Neo, Evosep One, UltiMate 3000) with full responsibility for daily/weekly maintenance, calibration, and troubleshooting
Deploying automation-supported workflows for high-throughput sample prep using platforms such as Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, or Dynamic Devices Lynx
Ensuring QC and reproducibility, including system suitability checks, performance tracking, and SOP documentation
Serving as proteomics point of contact for assigned drug discovery project teams. Collaborating with project leads to define experimental strategy, timelines, and expected results from the proteomics perspective
Communicating study design, progress, and results clearly to cross-functional team members (chemistry, biology, safety, DMPK, bioinformatics)
Demonstrating creativity and apply novel approaches to solving scientific problems. Propose novel and practical ideas, aligned with scientific strategies and demands
Qualification
Required
A Doctoral degree in Chemistry, Biochemistry, Chemical Biology, or a related field with 3+ years OR a Master's degree with 4+ years OR a Bachelor's degree with 6+ years of proven hands-on experience operating and troubleshooting LC-MS systems independently for proteomics (academic core or industry) is required
Experience with label-free proteomics workflows and robust sample preparation techniques as well as data processing suites Proteome Discoverer, MaxQuant, DIA-NN, Spectronaut, or Skyline
Excellent interpersonal and communication skills for cross-functional collaboration and project team engagement
Strong planning and project coordination skills with the ability to handle several projects at a time in a fast paced environment
Excellent interpersonal skills working with diverse colleagues
Preferred
Experience planning and performing target deconvolution/targeted protein degradation experiments
Expertise in PTM enrichment (phospho, ubiquitin, acetyl, glyco)
Familiarity with single-cell or spatial proteomics workflows
Industry drug discovery experience
Benefits
Medical
Dental
Vision
Life insurance
Short- and long-term disability
Business accident insurance
Group legal insurance
Consolidated retirement plan (pension)
Savings plan (401(k))
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member
Caregiver Leave – 10 days
Volunteer Leave – 4 days
Military Spouse Time-Off – 80 hours
Company
Johnson & Johnson Innovative Medicine
Johnson and Johnson Innovative Medicine focuses on developing medical solutions for some of the challenging diseases and medical conditions.
10001+ employees
Funding
Current Stage
Late StageLeadership Team
Molly Perkins
VP, Head of Cell & Genetic Medicines Discovery
Recent News
2025-08-14
Company data provided by crunchbase