Calico Life Sciences · 8 hours ago
Scientist/Senior Scientist, Structural Biology
South San Francisco, CA
Full-time
Onsite
Mid, Senior Level
$135K/yr - $191K/yr
0+ years expCalico is a research and development company focused on understanding human aging to enable healthier lives. They are seeking a Senior Scientist in Structural Biology to support research in aging and age-related diseases, involving protein structure determination and therapeutic design.
Biotechnology
Responsibilities
Design constructs and express and purify proteins for use in structural determination
Devise and implement strategies for determining protein structures by cryo-EM and/or X-ray crystallography using internal resources and working with contract research organization partners
Use software programs to solve, build, and refine protein structures and fit bound ligands
Present structural data to multiple groups at Calico to inform discovery programs
Record data in an electronic notebook and keep electronic data files well-organized
Qualification
Required
Ph.D. in biochemistry, biology, structural biology, biophysics, chemical biology, or a related discipline, and 0-5 years (for Scientist level) or 5+ years (for Senior Scientist level) of additional training in an industry or academic setting
A track record of experience in structural biology as evidenced by high profile publications
A deep understanding of protein structure and function and a strong background in protein biochemistry
Hands-on experience expressing proteins using various systems and purifying proteins with AKTA FPLCs using a variety of techniques
Hands-on experience in all aspects of cryo-EM structural determination including grid preparation, data processing, and structure building
Proficiency with protein structure software packages for model building (Coot), model refinement (Phenix), and molecular viewing (PyMOL and Chimera) is required
A strong desire to work on therapeutic discovery is necessary
Accountable, detail-orientated, and able to multitask
Self-motivated and able to work independently in a cross-functional team environment
Must be willing to work onsite 5 days a week
Preferred
Hands on experience with all steps of X-ray crystallography structural determination is a plus
A general understanding of other experimental protein structure determination methods and modeling techniques is an advantage
Prior experience working as part of a team in structure-based therapeutic optimization is an advantage
Benefits
Two annual cash bonuses
Company
Calico Life Sciences
Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.
201-500 employees
H1B Sponsorship
Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (12)
2023 (7)
2022 (10)
2021 (5)
2020 (14)
Funding
Current Stage
Growth StageLeadership Team
Ashley Archuleta
Sr. Administrative Assistant to the Chief Business Officer
Jonathan Lewis
Chief Business Officer
Recent News
Research & Development World
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