Glyphic Biotechnologies · 3 hours ago
Senior Research Associate, Reagents
Berkeley, CA
Full-time
Onsite
Mid, Senior Level
$82K/yr - $118K/yr
2+ years expGlyphic Biotechnologies is developing a revolutionary protein sequencing platform aimed at transforming life science discovery. They are looking for a highly motivated Senior Research Associate to execute and develop processes for the synthesis, purification, and characterization of oligonucleotides at scale, contributing to innovative projects at the intersection of synthetic chemistry, molecular biology, and biophysics.
BiotechnologyHealth CareLife Science
No H1B
Responsibilities
Collaborate closely with the project lead to execute daily oligonucleotide synthesis and purification requests using automated systems
Independently synthesize oligonucleotides at 200 nmol to >20 umol starting scales using MerMade 12, KnA H2 etc. and troubleshoot instrument issues
Actively propose ideas for new reagents and/or methods to reduce impurities such as deletions, alkylations etc. in synthesized oligos and resolve commonly observed problems in solid-phase oligo synthesis
Routinely handle moisture sensitive reagents such as phosphoramidites, acid anhydrides, dry solvents etc. and take necessary precautions to ensure high quality of reagents during synthesis
Develop and execute methods for purification of oligonucleotides to achieve n-1 resolution at semi-prep scale
Engage with the broader scientific team in discussions about oligo design and court ideas for expanding Glyphic’s oligonucleotide toolbox at all times
Effectively prioritize urgent synthesis requests to meet critical timelines
Provide routine updates to the project lead and the Reagents team in presentation form
Qualification
Required
BS/MS in Chemistry or Chemical Engineering with 2-3 years of experience in a synthetic chemistry lab
Hands-on experience with solid phase oligonucleotide synthesis and characterization (e.g., anion exchange/FPLC, HPLC)
Hands-on experience with moisture sensitive chemical reactions (e.g., phosphoramidite chemistry)
Familiarity with fundamental concepts of nucleotide chemistry, nucleophilic displacement reactions and biochemistry of DNA
Experience with purification of polar and/or non-polar compounds using at least one purification technique (e.g., RP-HPLC, Normal phase HPLC, HILIC, Size Exclusion Chromatography)
Legal authorization to work in the United States on a full-time basis. Visa sponsorship is not available for this role
Located in, or able to relocate to, the San Francisco Bay Area and available to start within two weeks of offer acceptance
Preferred
Hands-on experience operating LGC MerMade oligonucleotide synthesizers
Experience with LC-MS analysis of oligonucleotides and/or proteins
Ability to understand and resolve characterization outputs
Experience with bioconjugation reactions with DNA such as amide coupling, Cu-click, copper free click chemistry etc
Benefits
Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
Company
Glyphic Biotechnologies
Glyphic Biotechnologies is a biotechnology company that develops a protein sequencing platform.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$45.78MKey Investors
FoundersX VenturesLongeVCNational Institutes of Health
2025-09-26Series A· $38M
2024-11-25Seed
2024-01-25Seed
Leadership Team
Joshua Yang
Co-Founder and CEO
Daniel Estandian
CTO and Co-Founder
Recent News
Google Patent
2025-05-04
2025-05-04
2025-02-08
Company data provided by crunchbase