AbbVie · 14 hours ago
Senior Scientist I, siRNA in vitro Biology
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
8+ years expAbbVie is a company dedicated to discovering and delivering innovative medicines that address serious health issues. They are seeking a Senior Scientist I to lead in vitro siRNA discovery biology, design and execute experimental approaches, and collaborate across functions to support RNA-based therapies.
BiotechnologyFinancial ServicesHealth CareMedicalPharmaceuticalVenture Capital
Responsibilities
Independently lead in vitro siRNA discovery biology, including experimental strategy, assay design, execution, data analysis, and interpretation in support of active therapeutic programs
Design, optimize, and validate fit-for-purpose assays that directly inform siRNA potency, durability, specificity, and mechanism-of-action
Drive scientific decision making by integrating siRNA knockdown data with orthogonal readouts (protein, functional, and transcriptomic endpoints)
Identify and resolve key biological and technical risks related to siRNA activity, delivery, and on-target effects
Work with cross-functional partners (chemistry, delivery, bioinformatics, in vivo biology) to advance siRNA candidates through discovery milestones
Maintain high experimental rigor and productivity while operating with minimal supervision
Author internal technical reports and contribute as a primary author on publications and/or inventor on patents
Qualification
Required
BS, MS, or PhD in Cell Biology, Molecular Biology, Biochemistry, or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of relevant experience
Demonstrated, hands-on experience in siRNA therapeutic discovery is required, including ownership of in vitro siRNA studies that informed go/no-go, lead selection, or optimization decisions
Extensive experience with mammalian cell culture and molecular biology techniques directly supporting siRNA programs, including RNA isolation, qPCR, ELISA, Western blot, and nucleic acid sequencing (NGS/Sanger)
Proven ability to independently troubleshoot siRNA-specific challenges (e.g., variability in knockdown, assay sensitivity limits, off-target interpretation)
Strong data analysis and critical thinking skills, with a track record of translating complex datasets into clear experimental and programmatic recommendations
Preferred
Strong hands-on experience with stem-loop RT-qPCR, including assay design, optimization, validation, and data interpretation for siRNA and target mRNA quantification
Direct experience supporting antibody-based or antibody-enabled delivery strategies, including antibody conjugates or biologics-related development
Hands-on experience analyzing RNA-seq data generated from siRNA perturbation studies, including differential expression analysis and biological interpretation
Experience with siRNA sequence design and optimization, including target site selection and evaluation of structure–activity relationships
Familiarity with CNS-relevant biology and genetic medicine applications
Working knowledge of bioinformatics tools or scripting (e.g., R, Python) to interrogate high-dimensional RNA datasets
Experience operating effectively in a matrixed, fast-paced discovery organization
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Company
AbbVie
AbbVie is a biopharmaceutical company focused on immunology, oncology, neuroscience, virology, and aesthetics. It is a sub-organization of AbbVie.
10001+ employees
H1B Sponsorship
AbbVie has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (273)
2024 (190)
2023 (225)
2022 (284)
2021 (186)
2020 (186)
Funding
Current Stage
Public CompanyTotal Funding
$15B2024-02-27Post Ipo Debt· $15B
2023-03-08Post Ipo Equity· $0.25M
2012-12-20IPO
Leadership Team
Robert Michael
Chairman of the Board and Chief Executive Officer
Micah Bregman
Vice President, Global Strategy and Pipeline, Allergan Aesthetics
Recent News
2026-01-23
2026-01-20
2026-01-20
Company data provided by crunchbase