Wave Life Sciences · 16 hours ago
Postdoctoral Research Fellow (Drug Product Technical Services)
Lexington, MA, United States
Full-time
Onsite
New Grad, Entry Level
$81K/yr - $110K/yrWave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. This role involves developing oligonucleotide drug products for multiple clinical programs and provides exposure to the entire drug development lifecycle in a cross-functional team environment within the CMC group.
BiotechnologyHealth CarePharmaceuticalTherapeutics
Responsibilities
Design and execute formulation development studies to optimize oligonucleotide DP formulations
Conduct pre-formulation studies to assess physicochemical properties of various excipients and identify potential issues
Investigate the stability of formulations under different conditions and apply biophysical and analytical techniques to characterize molecular interactions and their impact on stability
Develop and implement analytical methods for characterizing oligonucleotide drug products using techniques such as pH meter, Osmometer, Densitometer, HPLC/UPLC, UV spectrophotometry/ Solo VPE, lyophilizer, DSC (Hands on experience on these instruments preferred)
Evaluate and implement new technologies for formulation improvement ensuring compliance with clinical and regulatory requirements
Collaborate with cross-functional teams within CMC to achieve project goals and assist with technology transfer activities at CMO
Present research findings at internal meetings and conferences
Maintain detailed records of experiments in Lab notebooks
Complete training and certifications on GLP practices and possess excellent literature review skills while sharing expertise with the team
Author and review technology transfer documentation including process descriptions, risk assessments, comparability protocols, and batch records
Participate in process scale-up, troubleshooting and root cause investigations during tech transfer campaigns
Qualification
Required
Ph.D. in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, or a related field
Strong background in drug product and formulation development, preferably with experience in oligonucleotide therapeutics
Proficiency in various analytical techniques used in formulation development
Experience with different formulation development strategies for parenteral delivery
Excellent problem-solving and data analysis skills
Strong communication skills for presenting scientific data
Ability to work independently and collaboratively in a team environment
Demonstrated scientific curiosity and a passion for advancing RNA medicines
Knowledge of applicable regulatory and quality standards (ICH, FDA, EMA) is desired
Benefits
Company-sponsored medical
Dental
Vision
Life
Long and short-term disability insurances
Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
401K participation with matching contributions
Company
Wave Life Sciences
Wave Life Sciences is a clinical-stage RNA medicines company committed to delivering life-changing treatments for people battling diseases
Founded in 2012
201-500 employees
H1B Sponsorship
Wave Life Sciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (15)
2024 (11)
2023 (15)
2022 (16)
2021 (15)
2020 (15)
Funding
Current Stage
Public CompanyTotal Funding
$1.22BKey Investors
GlaxoSmithKlineTakeda VenturesForesite Capital
2025-12-09Post Ipo Equity· $350M
2024-09-24Post Ipo Equity· $200M
2023-12-06Post Ipo Equity· $100M
Leadership Team
Paul Bolno
President and CEO
C
Chandra Vargeese
Chief Technology Officer and Head of Platform Discovery Sciences
Recent News
2026-01-06
2026-01-05
Company data provided by crunchbase