Voyager Therapeutics, Inc. · 8 hours ago
Scientist II, Protein Science
Lexington, MA
Full-time
Onsite
Mid, Senior Level
$120K/yr - $158K/yr
2+ years expVoyager Therapeutics, Inc. is a biotechnology company focused on curing neurological diseases through human genetics. They are seeking a Scientist II in Protein Science to design and develop fusion proteins and bispecific antibodies, collaborating with teams to ensure high-quality material for biotherapeutic candidates.
BiotechnologyGeneticsHealth CareLife Science
Responsibilities
Establish and optimize mammalian cell culture expression systems for recombinant fusion protein and antibody expression
Cell engineering, including stable cell line creation using various host cell lines
Lead the construction and design of complex DNA constructs for recombinant protein expression using standard and advanced molecular cloning strategies (restriction cloning, Gibson assembly, Golden Gate, site-directed mutagenesis)
Drive the optimization of cloning strategies to improve protein expression, solubility, and yields
Utilize various bioinformatic tools for expression construct design (e.g., codon optimization and stable domain boundary determination)
Design expression constructs incorporating various purification tagging strategies and complex multi-chain antibody formats that require chain pairing solutions
Perform PCR, restriction digestion, ligation, plasmid preparation, bacterial cell transformation, clone selection by colony PCR and DNA sequencing, and endotoxin-free DNA scale-up
Manage electronic plasmid and construct inventory, and cloning and expression queues
Collaborate with cross-functional teams (Protein Science & Bioconjugation, Neuroscience, and Bioinformatics) to design, troubleshoot, and scale molecule production for anticipated studies in a time-sensitive manner
Maintain accurate and up-to-date experimental records in electronic lab notebook
Qualification
Required
PhD or MS in biochemistry, protein or cell engineering or related field, with 2+ years or 9+ years respectively, of relevant industry experience
Proficiency using vector design tools and sequence analysis software for molecular biology; familiarity with high throughput cloning methods is desirable
Experience with multiple mammalian cell line hosts
Track record of success in designing functional stable, soluble fusion proteins
Ability to design and execute experiments and trouble-shoot challenges independently
Self-motivated with an ability to multitask different activities, e.g., cloning and expression
Outstanding analytical, research, and organizational skills
Excellent oral and written communication skills
Attention to detail is a must-have
Preferred
Experience with designing bispecific antibodies is preferable, i.e. familiarity with Fab, scFv, VHH, alternate linkers, heavy chain and light chain pairing solutions
Familiarity with protein purification methods (e.g., affinity tags such as His, Fc)
Technical experience with basic chromatographic separation techniques (affinity, ion-exchange, size exclusion) to isolate homogenous monodispersed protein is a plus
Company
Voyager Therapeutics, Inc.
Voyager Therapeutics, Inc.
51-200 employees
H1B Sponsorship
Voyager Therapeutics, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (7)
2023 (8)
2022 (1)
2021 (10)
2020 (5)
Funding
Current Stage
Public CompanyTotal Funding
$374MKey Investors
Neurocrine BiosciencesGenzymeThird Rock Ventures
2024-01-04Post Ipo Equity· $100M
2023-01-09Post Ipo Equity· $39M
2019-11-01Post Ipo Equity· $100M
Leadership Team
Trista Morrison
Senior Vice President, Corporate Affairs
Jacquelyn Fahey Sandell
Chief Legal Officer
Recent News
2026-01-03
2025-12-18
Labiotech UG
2025-12-09
Company data provided by crunchbase