Allergan Aesthetics, an AbbVie Company · 21 hours ago
Senior Scientist I, siRNA in vitro Biology
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$94K/yr - $178K/yr
8+ years expAbbVie is dedicated to solving some of the world’s most complex and serious diseases. They are seeking a Senior Scientist I with expertise in siRNA therapeutic discovery to design and execute innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics.
BeautyManufacturingPharmaceuticalWellness
Responsibilities
Independently lead in vitro siRNA discovery biology, including experimental strategy, assay design, execution, data analysis, and interpretation in support of active therapeutic programs
Design, optimize, and validate fit-for-purpose assays that directly inform siRNA potency, durability, specificity, and mechanism-of-action
Drive scientific decision making by integrating siRNA knockdown data with orthogonal readouts (protein, functional, and transcriptomic endpoints)
Identify and resolve key biological and technical risks related to siRNA activity, delivery, and on-target effects
Work with cross-functional partners (chemistry, delivery, bioinformatics, in vivo biology) to advance siRNA candidates through discovery milestones
Maintain high experimental rigor and productivity while operating with minimal supervision
Author internal technical reports and contribute as a primary author on publications and/or inventor on patents
Qualification
Required
BS, MS, or PhD in Cell Biology, Molecular Biology, Biochemistry, or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) of relevant experience
Demonstrated, hands-on experience in siRNA therapeutic discovery is required, including ownership of in vitro siRNA studies that informed go/no-go, lead selection, or optimization decisions
Extensive experience with mammalian cell culture and molecular biology techniques directly supporting siRNA programs, including RNA isolation, qPCR, ELISA, Western blot, and nucleic acid sequencing (NGS/Sanger)
Proven ability to independently troubleshoot siRNA-specific challenges (e.g., variability in knockdown, assay sensitivity limits, off-target interpretation)
Strong data analysis and critical thinking skills, with a track record of translating complex datasets into clear experimental and programmatic recommendations
Preferred
Strong hands-on experience with stem-loop RT-qPCR, including assay design, optimization, validation, and data interpretation for siRNA and target mRNA quantification
Direct experience supporting antibody-based or antibody-enabled delivery strategies, including antibody conjugates or biologics-related development
Hands-on experience analyzing RNA-seq data generated from siRNA perturbation studies, including differential expression analysis and biological interpretation
Experience with siRNA sequence design and optimization, including target site selection and evaluation of structure–activity relationships
Familiarity with CNS-relevant biology and genetic medicine applications
Working knowledge of bioinformatics tools or scripting (e.g., R, Python) to interrogate high-dimensional RNA datasets
Experience operating effectively in a matrixed, fast-paced discovery organization
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Short-term incentive programs
Company
Allergan Aesthetics, an AbbVie Company
At Allergan Aesthetics, an AbbVie company, we develop, manufacture, and market a portfolio of leading aesthetics brands and products.
1001-5000 employees
H1B Sponsorship
Allergan Aesthetics, an AbbVie Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2023 (1)
2022 (16)
2021 (14)
2020 (5)
Funding
Current Stage
Late StageLeadership Team
Nicole Mowad-Nassar
Senior Vice President, AbbVie and President, Global Allergan Aesthetics
Recent News
2025-12-04
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