Revolution Medicines · 19 hours ago
Scientist I, Computational Chemistry
Redwood City, California, United States
Full-time
Onsite
Entry, Mid Level
$119K/yr - $149K/yrRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The role of Scientist I involves driving drug discovery through computational methods, collaborating with multidisciplinary teams to optimize and accelerate the development of new drug candidates.
Health CareLife ScienceMedical
Responsibilities
Partner with multidisciplinary, collaborative teams in Discovery Sciences to design, optimize, and accelerate the discovery of novel drug candidates using structure-based computational methods
Analyze structure-activity relationships (SAR) and make data-driven decisions by systematically following existing SAR trends to guide compound prioritization and design strategies for Ro5 and bRo5 molecules
Partner closely with Medicinal Chemists to prioritize compound designs both independently and collaboratively, effectively communicating scientific rationale and recommendations to diverse interdisciplinary teams
Design and implement virtual screening workflows leveraging both structure-based and ligand-based computational methods to discover novel hit compounds and accelerate lead optimization processes
Leverage advanced computational methodologies, including physics-based methods, generative models and machine learning approaches, to enhance understanding of SAR and drive Ro5 and bRo5 projects with timely decision making to ensure focus and delivery of key objectives
Provide innovative ideas and models to challenge and guide project roadmap while serving as lead computational chemistry representative on drug discovery pipeline projects
Devise and execute strategies to augment our hit finding abilities for novel protein and protein-protein targets, aid in designing diverse chemical libraries
Qualification
Required
Ph.D. in computational chemistry or related field
Understanding of contemporary computational chemistry methods and their use in protein-ligand analysis and drug design such as docking, virtual screening, pharmacophore modeling, MD simulation, QM calculations etc
Experience with computational chemistry, cheminformatics, data science, machine learning software
Scientific programming or scripting in Bash, Python, R, Java, C languages, or similar languages
Excellent oral and written communication skills. Experience in positively influence team decisions and effectively collaborate across multidisciplinary environments
Driven by a desire to be innovative and creative in a high energy, fast-paced environment
Preferred
Experience with diverse Ro5 and bRo5 therapeutic modalities such as macrocycles and small molecules
Working in HPC environments
Strong publication history demonstrating computational chemistry expertise and innovation
Familiarity with data visualization tools and analytics tools for effective communication of insights
Benefits
Competitive cash compensation
Robust equity awards
Strong benefits
Significant learning and development opportunities
Company
Revolution Medicines
Revolution Medicines is an innovative and dynamic organization of expert biologists, chemists, pharmacologists, clinical scientists.
Founded in 2015
501-1000 employees
H1B Sponsorship
Revolution Medicines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (13)
2024 (18)
2023 (15)
2022 (8)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$2.25BKey Investors
Royalty PharmaBoxer CapitalNextech Invest
2025-06-24Post Ipo Debt· $250M
2024-12-02Post Ipo Equity· $750M
2023-03-02Post Ipo Equity· $323.6M
Leadership Team
Luan Wilfong
Chief Human Resources Officer
Steve Kelsey
President
Recent News
Pharmaceutical Technology
2026-01-13
Company data provided by crunchbase