Hexagon Bio · 19 hours ago
Scientist I/II, Protein Science
Menlo Park, CA
Full-time
Onsite
Entry, Mid Level
$120K/yr - $160K/yr
2+ years expHexagon Bio is a biotechnology company that utilizes a genomics-based platform to develop innovative ADCs for cancer treatment. They are seeking a motivated Scientist I/II to join their Protein Science team, focusing on ADC conjugation, purification, and analytical characterization to support their expanding pipeline.
BiotechnologyHealth CareTherapeutics
Responsibilities
Perform antibody-drug conjugation at milligram to gram scale using a variety of linker chemistries and conjugation strategies
Purification of conjugated antibodies via TFF (tangential flow filtration) and FPLC-based purifications (SEC, IEX, HIC and other chromatography-based methods)
Optimize reaction conditions, monitor conjugation efficiency, and ensure consistency across production batches
Execute analytical assays to assess ADC properties and quality, including: SEC, HIC, IEX, RP-HPLC, UV-Vis, LC-MS DAR determination, SDS-PAGE, endotoxin, DSF and light scattering
Design and troubleshoot experiments, analyze data and communicate results clearly to project teams
Collaborate with cell biology teams to ensure materials meet criteria for potency assays, in vitro MoA studies, and in vivo PK/efficacy/tolerability experiments
Identify workflow limitations and implement process improvements to increase throughput and reproducibility
Maintain detailed electronic laboratory notebooks
Comply with safety policies and best laboratory practices
Contribute to a collaborative, transparent, and mission-driven team culture
Qualification
Required
PhD. in Biochemistry, Chemistry, Structural Biology, or related discipline
2-4 years of hands-on industry experience, preferably in protein sciences or related area
Direct experience with ADC conjugation, protein purification, or analytical characterization is strongly preferred
Hands-on experience with ÄKTA/FPLC chromatography systems including preparative HIC, IEX and SEC
Strong analytical and troubleshooting abilities
Excellent organization, communication, and documentation skills
Curiosity, initiative, and the ability to excel in a dynamic startup environment
Preferred
Experience with ÄKTA method development and maintenance is a plus
Hands-on experience with HPLC based analytical methods such as SEC, IEX, HIC, RP-HPLC, and UV-Vis
Hands-on experience with LC-MS and DSF / Light scattering is a plus
Benefits
A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.
All Hands Meetings provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
Rapid career advancement for driven performers.
Access to scientific conferences throughout the year.
A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sauna, sports courts, cafe, bike lockers, and free EV charging stations.
Opportunities to engage with the Hexagon community through team-building events like our Hexagon Happy Hours and holiday parties.
Company
Hexagon Bio
Hexagon Bio is a data-driven biotech company developing targeted small molecule therapeutics.
51-200 employees
H1B Sponsorship
Hexagon Bio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2023 (4)
2022 (1)
Funding
Current Stage
Growth StageTotal Funding
$193.6MKey Investors
Nextech InvestThe Column Group8VC
2022-10-11Series B· $77.3M
2021-09-22Series Unknown· $61M
2020-09-15Series A· $47M
Leadership Team
Maureen Hillenmeyer
Founder and CEO
Recent News
2025-12-19
2025-12-16
2025-12-16
Company data provided by crunchbase