Revolution Medicines · 17 hours ago
Senior Director, Clinical Pharmacology
Redwood City, California, United States
Full-time
Hybrid
Director/Executive
$244K/yr - $305K/yr
8+ years expRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The Senior Director of Clinical Pharmacology will lead the design and execution of clinical pharmacology strategies and ensure the delivery of the clinical pipeline through key milestones.
Health CareLife ScienceMedical
Responsibilities
Responsible for clinical pipeline delivery through major milestones including IND/CTA, EOP2, and marketing applications NDA/sNDA
Lead the design and execution of an integrated clinical pharmacology and modeling and simulation strategy to guide the clinical development plan
Apply state-of-the-art quantitative pharmacology analyses, including population PK, exposure-response analyses, to guide dose/schedule selection and recommended phase 2 dose and schedule (RP2Ds) selection
Author and provide technical input for regulatory documents and submissions related to all aspects of clinical pharmacology (including protocol, CSR, IB, briefing package, SCP/SBS, label etc.) and responses to regulatory questions
Engage and work with consultants and/or CROs on clinical pharmacology activities to complement in-house knowledge/expertise and capacities
Represent the clinical pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions
Ability to manage internship and fellowship programs
Qualification
Required
A Ph.D. or PharmD or equivalence with minimum of 8-10 years of relevant industry experience in Clinical and Quantitative pharmacology
Expertise in clinical pharmacology, hands-on modeling, and simulation skills using NONMEM, R, and/or other modeling and simulation software
Experience with population PK, exposure-response, and advanced mechanistic PK/PD models
Track record of applying modeling and simulation methodologies to inform and accelerate drug development
Well-informed in current and emerging scientific standards of regulatory requirements and expectations
Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences
Strong interpersonal skills, and ability to influence development project and management teams
A critical thinker and passionate team player with high energy who thrives in a dynamic and fast-paced environment
Preferred
Prior experience with small molecules in oncology drug development
Proven successful industry experience in oncology submissions in the US, EU and Asia
Benefits
Competitive cash compensation
Robust equity awards
Strong benefits
Significant learning and development opportunities
Company
Revolution Medicines
Revolution Medicines is an innovative and dynamic organization of expert biologists, chemists, pharmacologists, clinical scientists.
501-1000 employees
H1B Sponsorship
Revolution Medicines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (13)
2024 (18)
2023 (15)
2022 (8)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$2.25BKey Investors
Royalty PharmaBoxer CapitalNextech Invest
2025-06-24Post Ipo Debt· $250M
2024-12-02Post Ipo Equity· $750M
2023-03-02Post Ipo Equity· $323.6M
Leadership Team
Luan Wilfong
Chief Human Resources Officer
Steve Kelsey
President
Recent News
Pharmaceutical Technology
2026-01-13
Company data provided by crunchbase