Alnylam Pharmaceuticals · 1 hour ago
Principal Scientist, Antibody Cell Line Development
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$147K/yr - $221K/yr
6+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, seeking a Principal Scientist to join their Protein Sciences team. The role involves driving cell line and upstream process development for monoclonal antibodies and overseeing activities at selected CDMOs to ensure smooth transitions from discovery to clinical readiness.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Lead the development, selection, and characterization of stable, high-titer cell lines for the production of monoclonal antibodies and antibody-oligo conjugates
Evaluate, select, and manage CDMOs to execute regulatory-compliant cell line development activities including clonality documentation and cell bank generation
Supervise all cell line development processes including construct design, generation of stable pools, clone screening, characterization, and cell line stability
Analyze protocols, development reports, and other data packages generated by CDMOs
Ensure activities completed at CDMOs align with project goals, timelines, and quality standards
Support regulatory filings by authoring and reviewing relevant sections related to cell line development
Work cross-functionally with internal teams including research, CMC, regulatory, and clinical to ensure seamless transfer of knowledge
Contribute to a cross-functional team of biologists, chemists, and pharmacologists to drive the strategic direction of research programs across multiple therapeutic modalities
Qualification
Required
Ph.D. in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences, Biology, or related field with 6-10 years of relevant experience
Deep expertise in cell line development for production of therapeutic proteins including monoclonal antibodies, antibody-drug conjugates, or antibody-oligo conjugates
Strong technical background in all aspects of cell line development including molecular biology, vector design, single cell cloning technologies, cell line characterization, and industry-leading antibody production platforms
Proven track record of managing CDMOs and delivering on biologics development programs
Experience working across multiple projects simultaneously in a fast-paced, cross-functional environment
Excellent written/oral communication, organizational, and interpersonal skills are required to work effectively across teams
Preferred
Additional expertise in antibody design and protein engineering is a plus
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
Clinical Trials Arena
2026-01-16
Longevity.Technology
2026-01-14
2026-01-13
Company data provided by crunchbase