Glyphic Biotechnologies · 11 hours ago
Staff/Senior Scientist, Proteomics
Berkeley, CA
Full-time
Onsite
Senior Level, Lead/Staff
$123K/yr - $188K/yr
6+ years expGlyphic Biotechnologies is developing a groundbreaking single-molecule proteome sequencing platform aimed at revolutionizing life science discovery. They are seeking a highly analytical and collaborative Staff/Senior Scientist to lead the advancement of proteomics technologies and workflows, working closely with a multidisciplinary team to drive high-throughput solutions.
BiotechnologyHealth CareLife Science
Responsibilities
Develop and optimize sample preparation workflows for proteomics across diverse biological matrices, including cells and tissues
Design and execute methods to isolate cell surface proteins, including chemical labeling and enrichment approaches
Apply and innovate protein and peptide enrichment strategies (e.g., affinity capture, fractionation, PTM-specific enrichment)
Assess new sample types, determine appropriate analytical strategies, and develop protocols for protein extraction and purification
Collaborate with chemists and engineers to scale workflows and integrate protocols into high-throughput and automated platforms
Design and execute mass spectrometry–based proteomics experiments, including discovery, targeted, and quantitative workflows
Apply peptide chemistry techniques, including synthesis, modification, labeling, and derivatization
Utilize chemical biology tools such as probes, crosslinkers, and activity-based reagents to interrogate protein function and interactions
Operate, optimize, and troubleshoot LC–MS/MS systems (e.g., Q-TOF, Astral, nanoLC)
Develop acquisition methods tailored to sensitivity, coverage, and quantitative accuracy
Evaluate and compare LC–MS–based proteomics workflows against orthogonal protein sequencing and characterization technologies, such as antibody-based methods, Edman sequencing, single-molecule protein sequencing, or emerging proteomics platforms
Process, analyze, and critically evaluate complex proteomics datasets
Use industry-standard proteomics software and pipelines (e.g., MaxQuant, Proteome Discoverer, Skyline, Spectronaut, PEAKS, or equivalent)
Perform quantitative and statistical analysis to assess data quality, reproducibility, and biological relevance
Stay current with advances in proteomics technologies and advise on platform selection and experimental strategy
Work cross-functionally with chemists, biologists, computational scientists, and engineers
Document methods, generate SOPs, and contribute to best practices
Present results clearly to technical and non-technical audiences
Qualification
Required
Industry experience relevant to the role and an advanced degree in Proteomics, Chemical Biology, Biochemistry, Analytical Chemistry, or a related field including: MS/PhD with 8+/6+ years (for Staff Scientist) MS/PhD with 6+/4+ years (for Senior Scientist)
Strong hands-on experience with LC–MS/MS–based proteomics
Demonstrated expertise in sample preparation, protein extraction, and enrichment strategies (chemical biology/enrichment strategies preferred)
Proven ability to analyze, interpret, and evaluate mass spectrometry data
Solid understanding of protein chemistry, post-translational modifications, and quantitative proteomics
Excellent problem-solving skills and attention to detail
Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds
Ability to thrive in a fast-paced environment with evolving priorities
Preferred
Experience with cell surface proteomics or chemical labeling approaches
Experience with solid phase peptide chemistry
Familiarity with high-throughput proteomics workflows, automation and sample multiplexing
Experience evaluating or implementing alternative protein sequencing or characterization technologies (e.g., O-Link or SomaScan proteomics)
Working knowledge of bioinformatics tools or scripting (e.g., R, Python)
Track record of publications, patents, or technology development
Benefits
Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
Company
Glyphic Biotechnologies
Glyphic Biotechnologies is a biotechnology company that develops a protein sequencing platform.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$45.78MKey Investors
FoundersX VenturesLongeVCNational Institutes of Health
2025-09-26Series A· $38M
2024-11-25Seed
2024-01-25Seed
Leadership Team
Joshua Yang
Co-Founder and CEO
Daniel Estandian
CTO and Co-Founder
Recent News
Google Patent
2025-05-04
2025-05-04
2025-02-08
Company data provided by crunchbase