Prima Mente · 1 month ago
Bioinformatics Engineer - Virtual Cells
San Francisco, CA
Full-time
Hybrid
Mid, Senior LevelPrima Mente is a frontier biology AI lab focused on understanding and enhancing brain health. They are seeking a Bioinformatics Engineer to articulate biological hypotheses related to neurological diseases using a virtual cell model, develop bioinformatics pipelines, and collaborate with research partners.
Artificial Intelligence (AI)BiotechnologyNeuroscience
Responsibilities
Set up and framework experimental hypotheses focussed on available datasets and models, with downstream evaluation criteria to assess performance
Identify and curate public and proprietary datasets across different multi-omic, multi-modal types
QC and data analysis
Multi-omic bioinformatics pipeline development
Feature engineering and dataset preparation for downstream machine learning as well as foundational AI training and application
Work with experimental and machine learning teams to confirm and refine computational findings
Develop and manage specific external research collaborations with academic and industrial partners specific to AD biology
Qualification
Required
Strong experience representing cellular state from transcriptomic and/or multi-omic data
Hands-on exposure to perturbation datasets and methods for modeling state transitions
Strong, practical understanding of cellular state change and how to leverage it to study and explain disease
Top tier publications
Patent experience
First-hand experience with generating biological insights from biological data for virtual cells (genomics, epigenetics, transcriptomics, proteomics, ATAC-Seq)
Operational software engineering skills: the ability to write high-quality code to be the backbone of our software stack
Experience with end-to-end tools used to process multi-omic data from raw data all the way to analytical outputs
Good working knowledge of workflow managers, including but not limited to NextFlow
Expertise with statistical approaches applied to evaluating biological datasets
Strong working knowledge with cloud computing environments, including but not limited to AWS
Domain knowledge with advanced artificial intelligence approaches and experience applying them to a biological context
Familiar with data wrangling, analysis, and visualisation libraries using Python (preferable), R or Julia
Strong data engineering knowledge, including but not limited to experience with Spark, Hadoop, NoSQL
Preferred
Familiarity with encoders and probabilistic/distributional modeling
Company
Prima Mente
The AI Biology company.
Founded in 2022
11-50 employees
Funding
Current Stage
Early StageTotal Funding
unknownKey Investors
Innovate UK
2024-03-20Grant
2023-01-01Seed
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