Mass General Brigham · 8 hours ago
Research Lab Technologist Senior
Boston, MA
Full-time
Onsite
Mid, Senior Level
$51K/yr - $82K/yr
5+ years expMass General Brigham is dedicated to advancing patient care, research, teaching, and community service. The Research Lab Technologist Senior will support the development and execution of high complexity molecular assays for clinical diagnostics and public health genomic surveillance, collaborating closely with the CDC and local health departments.
Health CareHome Health CareMedical
Responsibilities
Perform and optimize nucleic acid extraction workflows (manual and/or automated) for a variety of human clinical specimen types; implement extraction controls and contamination prevention practices
Develop, optimize, and troubleshoot high-complexity molecular assays including RT-qPCR, qPCR, and digital PCR. Prepare and interpret run level QC metrics and troubleshoot pre-analytical and analytical issues
Prepare NGS libraries (e.g., metagenomic or amplicon approaches) and perform target enrichment (hybrid capture) workflows. Quantify and QC libraries, sequence using Illumina and Oxford Nanopore approached, and perform first level analysis, QC, and interpretation of sequencing results
Operate, monitor, and perform routine maintenance for sequencing instruments and supporting laboratory equipment. Document instrument performance and coordinate service as needed
Plan and execute assay development and validation studies and summarize results in organized validation reports
Maintain accurate documentation (lab notebook, SOPs, batch records, QC logs, incident reporting, and sample chain of custody) and follow institutional biosafety and data security requirements
Support specimen biorepository operations including specimen receipt, processing/aliquoting, labeling, storage, inventory management, and sample and data tracking in laboratory information management systems
Coordinate daily laboratory operations including reagent preparation, inventory management, ordering, and tracking of supplies
Perform primary data review and interpretation for molecular and sequencing outputs; collaborate with bioinformatics partners and utilize platforms such as Terra and standard analytical tools for QC summaries and reporting
Communicate effectively with supervisors and collaborators regarding assay status, issues, and timelines. Contribute to method write ups, protocols, abstracts/manuscripts, federal assay approval submissions, and internal training as needed
Qualification
Required
A bachelor's degree in a biological, biomedical, biotechnology, or other relevant scientific field is required
A minimum of 5 years of relevant experience is required (or a minimum of 2 years for candidates with a master's degree)
Perform and optimize nucleic acid extraction workflows (manual and/or automated) for a variety of human clinical specimen types; implement extraction controls and contamination prevention practices
Develop, optimize, and troubleshoot high-complexity molecular assays including RT-qPCR, qPCR, and digital PCR. Prepare and interpret run level QC metrics and troubleshoot pre-analytical and analytical issues
Prepare NGS libraries (e.g., metagenomic or amplicon approaches) and perform target enrichment (hybrid capture) workflows. Quantify and QC libraries, sequence using Illumina and Oxford Nanopore approached, and perform first level analysis, QC, and interpretation of sequencing results
Operate, monitor, and perform routine maintenance for sequencing instruments and supporting laboratory equipment. Document instrument performance and coordinate service as needed
Plan and execute assay development and validation studies and summarize results in organized validation reports
Maintain accurate documentation (lab notebook, SOPs, batch records, QC logs, incident reporting, and sample chain of custody) and follow institutional biosafety and data security requirements
Support specimen biorepository operations including specimen receipt, processing/aliquoting, labeling, storage, inventory management, and sample and data tracking in laboratory information management systems
Coordinate daily laboratory operations including reagent preparation, inventory management, ordering, and tracking of supplies
Perform primary data review and interpretation for molecular and sequencing outputs; collaborate with bioinformatics partners and utilize platforms such as Terra and standard analytical tools for QC summaries and reporting
Communicate effectively with supervisors and collaborators regarding assay status, issues, and timelines. Contribute to method write ups, protocols, abstracts/manuscripts, federal assay approval submissions, and internal training as needed
Demonstrated proficiency with high-complexity molecular laboratory techniques (nucleic acid extraction, RT-qPCR/qPCR, digital PCR, and NGS library preparation with target enrichment) and a strong track record of troubleshooting and optimization
Direct experience with target enrichment workflows (hybrid capture/target capture) and best practices for RNA and DNA handling, contamination prevention, and appropriate experimental design
Ability to generate, review, and interpret QC metrics, maintain organized records, and follow SOPs and biosafety requirements in a clinical and research laboratory setting
Ability to work independently on multiple concurrent assay development efforts or projects while meeting timelines. Strong organizational skills and attention to detail are required
Strong communication skills, including the ability to document methods clearly, summarize results, and communicate technical issues to interdisciplinary teams
Comfort with basic data analysis and visualization using common tools (e.g., Excel, GraphPad Prism) and familiarity with cloud based sequencing data analysis environments (e.g., Terra) is required
Preferred
A master's degree in a relevant field is preferred
Benefits
Comprehensive benefits
Career advancement opportunities
Differentials
Premiums
Bonuses
Recognition programs designed to celebrate your contributions and support your professional growth
Company
Mass General Brigham
Mass General Brigham specializes in providing medical treatments and health diagnostics services.
10001+ employees
H1B Sponsorship
Mass General Brigham has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (77)
2024 (61)
2023 (93)
2022 (70)
2021 (80)
2020 (29)
Funding
Current Stage
Late StageLeadership Team
E
Erin Flanigan
SVP, Human Resources, Community, Specialty Hospital Division
O’Neil A. Britton
Chief Integration Officer, Executive Vice President
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