Personalis, Inc. · 1 day ago
Director, Informatics Project Portfolio Management
Fremont, CA
Full-time
Hybrid
Director/Executive
$215K/yr - $260K/yr
10+ years expPersonalis is transforming cancer management through personalized testing and advanced insights. The Director of Informatics Project Portfolio leads the planning and delivery of informatics initiatives that support clinical diagnostics and laboratory operations, ensuring compliance with regulatory standards and business strategy.
BiotechnologyGeneticsHealth CareHealth Diagnostics
Responsibilities
Own the informatics project portfolio across clinical, laboratory, and enterprise data systems
Establish and lead portfolio governance, intake, and prioritization processes aligned with business, clinical, and regulatory priorities
Partner with executive leadership to balance innovation, operational stability, compliance, and scalability
Ensure portfolio alignment with quality systems, validation requirements, and regulatory expectations
Oversee multiple complex, cross-functional informatics programs, including LIMS, clinical data platforms, analytics, and software applications
Ensure projects follow appropriate SDLC, CSV (Computer System Validation), and design control processes
Drive clear definition of scope, milestones, dependencies, risks, and success metrics
Proactively manage risks related to data integrity, system validation, regulatory compliance, and clinical impact
Serve as a key integrator across Informatics, IT, Software Engineering, Clinical Operations, Laboratory Operations, Quality, Regulatory, and Product teams
Facilitate decision-making across stakeholders with competing priorities and regulatory constraints
Communicate portfolio status, trade-offs, risks, and outcomes to senior and executive leadership
Ensure informatics initiatives comply with applicable regulations and standards (e.g., CLIA, CAP, HIPAA, FDA 21 CFR Part 11, ISO 13485, GxP as applicable)
Partner with Quality and Regulatory teams to ensure proper documentation, validation, and audit readiness
Embed data governance, security, and privacy best practices into portfolio execution
Qualification
Required
Masters degree in Informatics, Computer Science, Life Sciences, or a related field
10+ years of experience in project, program, or portfolio management within healthcare, diagnostics, life sciences, or regulated environments
Demonstrated experience leading informatics, clinical data, or laboratory systems initiatives
Strong understanding of healthcare data systems and informatics workflows
Proven experience working within regulated, quality-driven organizations
Excellent executive communication and stakeholder management skills
Technical fluency in healthcare informatics systems
Risk-based decision making with patient impact in mind
Ability to assess impact and define proportionate controls
Preferred
Advanced degree (MS, MBA, MPH, or PhD)
Experience with diagnostics, genomics, or precision medicine platforms
Experience with CSV, SDLC, delivery in regulated environments
Familiarity with LIMS, Clinical systems, QMS, eQMS, or other lab and quality informatics platforms preferred
Benefits
Medical
Dental
Vision
401(k) match
ESPP
Tuition reimbursement
Sick/vacation time
Commuter benefits/ EV charging stations
Onsite gym
Wellness benefits
Company
Personalis, Inc.
At Personalis, we are transforming the active management of cancer through breakthrough personalized testing.
201-500 employees
H1B Sponsorship
Personalis, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (6)
2024 (10)
2023 (17)
2022 (19)
2021 (12)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$311.25MKey Investors
MerckTempusLightspeed Venture Partners
2024-12-19Post Ipo Equity· $50M
2024-08-16Post Ipo Equity· $36.15M
2021-01-27Post Ipo Equity· $150.1M
Leadership Team
Aaron Tachibana
Chief Financial Officer
Christian Haudenschild
Senior Vice President
Recent News
2026-01-09
2026-01-09
Company data provided by crunchbase