C4 Therapeutics, Inc. · 21 hours ago
Principal Scientist, Structural Biology
Watertown, MA, US
Full-time
Onsite
Lead/Staff
$172K/yr - $190K/yr
8+ years expC4 Therapeutics is a clinical-stage biopharmaceutical company focused on targeted protein degradation to create innovative medicines. The Principal Scientist will apply structural biology techniques to support the discovery and development of small molecule targeted protein degraders, collaborating with various scientific teams and managing external partners.
Health DiagnosticsMedicalTherapeutics
Responsibilities
Maintain state-of-the-art capabilities for structural biology through managing CROs in order to support E3 ligase and therapeutic target ligand discovery and optimization, binary and ternary complex characterization and small molecule degrader design
Contribute to drug discovery projects using X-ray crystallography and cryo-EM techniques through management of our CRO partners
Contribute structural biology guidance in both the design of protein constructs used in hit identification screens and in further compound progression efforts
Establish and maintain strong productive relationships with strategic partners and collaborators
Work as a leader and colleague across functional areas to help drive structure-based drug discoveries throughout our portfolio
Qualification
Required
A PhD in Structural Biology, Biophysics, or a related field with a minimum of eight years of experience in a Life Science setting; additional experience can compensate for required education
Deep understanding and extensive experience with X-ray crystallography
Familiarity with in vitro biochemical and biophysical methods such as SPR, FP, FRET, ITC, and their application to structure activity relationships
Experience with small-molecule drug discovery and effectively introducing relevant new technologies to a company environment
Experience in managing CROs
Preferred
Experience with cryoEM and/or familiarity with other structural methods such as HDX-MS and SAXS
Experience with DNA encoded library (DEL) platforms
Company
C4 Therapeutics, Inc.
C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives.
51-200 employees
H1B Sponsorship
C4 Therapeutics, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (1)
2023 (1)
2022 (3)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$423.8MKey Investors
RA Capital ManagementBetta PharmaceuticalsPerceptive Advisors
2025-10-16Post Ipo Equity· $125M
2023-05-30Post Ipo Equity· $25M
2022-08-15Post Ipo Equity
Leadership Team
Kendra Adams
Chief Financial Officer
Recent News
BioWorld Financial Watch
2026-01-16
Company data provided by crunchbase