Flagship Pioneering · 5 hours ago
Associate Director, In Vivo Pharmacology & Translational Science
Cambridge, MA USA
Full-time
Onsite
Mid, Senior Level, Lead/Staff
$157K/yr - $198K/yr
5+ years expFlagship Labs 111 Inc. (FL111) is an early-stage biotechnology company pioneering a novel platform in chemistry and machine learning. The Associate Director will lead in vivo activities from early discovery through preclinical development, focusing on the design, execution, and interpretation of in vivo studies, particularly in oncology.
FinanceFinancial ServicesVenture Capital
Responsibilities
Project leadership: serve as the in vivo lead on project teams, accountable for end-to-end planning, execution, and delivery of all in vivo PK, PD, and efficacy studies
Study design and execution: develop and execute in vivo studies to evaluate compound exposure (PK), target engagement and biomarkers (PD), and anti-tumor activity (efficacy) across various oncology models and small molecule modalities; hands-on execution
CRO management and operations: lead the day-to-day management of external in vivo work at CROs, including protocol review, study monitoring, data quality oversight, and vendor qualification/onboarding
Collaborate closely with Chemistry, DMPK, and Biology teams to refine compound design and formulation based on integrated PK/PD/efficacy data
Documentation & Communication: Establish fit-for-purpose in vivo workflows and SOPs, document experiments & results, and communicate scientific results effectively through clear presentations
Qualification
Required
Ph.D./M.D. with 5-10+ years of industry experience in preclinical development of small molecule modalities
Deep expertise in Oncology and Cancer Biology, specifically in designing and executing studies using diverse in vivo oncology models (e.g., CDX, PDX, humanized, syngeneic)
Expertise in the preclinical characterization of heterobifunctional small molecules (e.g., PROTACs)
Proven ability to lead projects, integrating PK, PD, and efficacy data to drive compound optimization and Go/No Go decisions
Extensive experience managing external in vivo work at CROs, including experimental design, study monitoring, and data quality oversight
Benefits
Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of other benefits
Company
Flagship Pioneering
Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.
501-1000 employees
H1B Sponsorship
Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (4)
2023 (4)
2022 (4)
2021 (1)
Funding
Current Stage
Late StageLeadership Team
Noubar Afeyan
Founder and CEO
Chuck Carelli
Chief Financial Officer
Recent News
2026-01-16
2026-01-16
Company data provided by crunchbase