City of Hope · 18 hours ago
Research Associate I - Cancer Genomics
Monrovia, CA
Full-time
Onsite
New Grad, Entry Level
$25/hr - $29/hr
0+ years expCity of Hope is at the forefront of groundbreaking research, changing lives in the fight against cancer and other life-threatening illnesses. The Research Associate I will perform bioinformatics and computational analyses in support of leukemia genomics and biomedical research projects, focusing on next-generation sequencing data analysis and workflow development.
AssociationEducationHealth Care
Responsibilities
Use high-performance computing (HPC) servers and established analytical pipelines to perform bioinformatics and statistical analyses on large-scale NGS datasets, including bulk RNA-seq, whole-genome sequencing (WGS), whole-exome sequencing (WES), circRNA, and single-cell RNA-seq (scRNA-seq). Execute quality control, alignment, quantification, variant analysis, and downstream statistical workflows using Python, R, and Linux-based tools. Record, verify, and document analytical results to ensure accuracy, reproducibility, and completeness
Contribute to the development, maintenance, and refinement of Snakemake-based bioinformatics workflows, including modular pipeline components for data preprocessing, quality control, alignment, and downstream analysis. Assist with improving computational efficiency, robustness, and reproducibility of existing pipelines
Build, maintain, and curate structured metadata databases supporting large-scale omics projects, enabling traceability, reproducibility, and efficient cross-project data access. Ensure consistent data organization and documentation standards across multiple research studies
Generate organized output files, summary reports, and data visualizations to support biological interpretation and communication within interdisciplinary research teams. Write standard analytical procedures, documentation, and internal reports to support knowledge sharing and long-term project continuity
Develop and expand expertise in bioinformatics methodologies relevant to leukemia genomics and related research areas, including differential expression analysis, clustering, dimensionality reduction, and variant interpretation. Apply quantitative reasoning and statistical principles to support hypothesis-driven research
Ensure that all computational and data-related activities comply with City of Hope policies, data security requirements, and institutional standards for research integrity, confidentiality, and responsible conduct of research
Qualification
Required
Bachelor's degree in Engineering, Bioinformatics, Data Science, or a related quantitative discipline, with strong emphasis on mathematical modeling, statistics, and computational analysis
0-2 years of research/laboratory experience
Company
City of Hope
City of Hope is a cancer research and treatment non-profit organization specializing in diabetes and other life-threatening illnesses.
10001+ employees
Funding
Current Stage
Late StageTotal Funding
$10.3MKey Investors
California Institute for Regenerative Medicine
2024-05-20Grant· $5.4M
2022-02-22Grant· $4.9M
Leadership Team
Samuel Lau
Vice President Marketing & Digital Communications
Alan H. Bryce
Chief Clinical Officer
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