Research Associate I - Cancer Genomics jobs in United States
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CHA Hollywood Presbyterian Medical Center · 2 hours ago

Research Associate I - Cancer Genomics

CHA Hollywood Presbyterian Medical Center is at the forefront of groundbreaking research, focusing on innovative approaches to combat cancer and other life-threatening illnesses. They are seeking a Research Associate I to perform bioinformatics and computational analyses in support of leukemia genomics and other biomedical research projects, emphasizing next-generation sequencing and structured data management.

Health CareHospitalMedical

Responsibilities

Use high-performance computing (HPC) servers and established analytical pipelines to perform bioinformatics and statistical analyses on large-scale NGS datasets, including bulk RNA-seq, whole-genome sequencing (WGS), whole-exome sequencing (WES), circRNA, and single-cell RNA-seq (scRNA-seq). Execute quality control, alignment, quantification, variant analysis, and downstream statistical workflows using Python, R, and Linux-based tools. Record, verify, and document analytical results to ensure accuracy, reproducibility, and completeness
Contribute to the development, maintenance, and refinement of Snakemake-based bioinformatics workflows, including modular pipeline components for data preprocessing, quality control, alignment, and downstream analysis. Assist with improving computational efficiency, robustness, and reproducibility of existing pipelines
Build, maintain, and curate structured metadata databases supporting large-scale omics projects, enabling traceability, reproducibility, and efficient cross-project data access. Ensure consistent data organization and documentation standards across multiple research studies
Generate organized output files, summary reports, and data visualizations to support biological interpretation and communication within interdisciplinary research teams. Write standard analytical procedures, documentation, and internal reports to support knowledge sharing and long-term project continuity
Develop and expand expertise in bioinformatics methodologies relevant to leukemia genomics and related research areas, including differential expression analysis, clustering, dimensionality reduction, and variant interpretation. Apply quantitative reasoning and statistical principles to support hypothesis-driven research
Ensure that all computational and data-related activities comply with City of Hope policies, data security requirements, and institutional standards for research integrity, confidentiality, and responsible conduct of research

Qualification

BioinformaticsNext-Generation SequencingPythonRHigh-Performance ComputingData ManagementStatistical AnalysisTeam CollaborationDocumentationCommunication

Required

Bachelor's degree in Engineering, Bioinformatics, Data Science, or a related quantitative discipline, with strong emphasis on mathematical modeling, statistics, and computational analysis
0-2 years of research/laboratory experience

Benefits

Comprehensive Benefits

Company

CHA Hollywood Presbyterian Medical Center

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CHA Hollywood Presbyterian Medical Center is a full-service, acute care hospital. It serves multicultural communities with quality medical.