Gossamer Bio · 1 day ago
Principal Scientist Bioinformatics
San Diego, California, United States
Full-time
Onsite
Senior Level, Lead/Staff
$181K/yr - $195K/yr
5+ years expGossamer Bio is seeking a highly capable bioinformatics expert to join their Translational Medicine team as a Principal Scientist, Bioinformatics. This role involves leading bioinformatics efforts, developing analytical workflows, and collaborating with cross-functional teams to drive biomarker and multi-omics analyses in clinical programs focused on pulmonary disease.
BiotechnologyHealth CareTherapeutics
Responsibilities
Lead computational biology and bioinformatics efforts within active therapeutic programs
Partner closely with Translational Research, Clinical Development and Biometrics to shape biomarker strategies and analysis plans
Perform study-level analyses of exploratory clinical biomarker data (including proteomics, transcriptomics, imaging) to assess mechanism of action, identify molecular drivers of remission and characterize therapeutic response
Conduct analyses to support preclinical translational research and exploratory biology studies to inform clinical development programs and business development objectives, including mechanism validation, target assessment, and responder biology
Develop and apply ML/AI models to characterize patient trajectories and identify responder subgroups
Generate high-quality data visualizations, summaries, and analyses to support manuscripts, abstracts, regulatory submissions and internal communication and decision-making
Communicate findings clearly and effectively to both technical and non-technical stakeholders, contributing to program strategy and direction
Serve as a computational thought partner to scientific leadership across programs
Qualification
Required
Ph.D. in Bioinformatics, Computational Biology, Systems Biology, Biostatistics or related field
5-10+ years of relevant experience in biotech or pharmaceutical industry roles, ideally supporting therapeutic development programs
Strong understanding of biology and translational research, with demonstrated ability to address biological questions using computational approaches
Demonstrated experience in analysis and biological interpretation of multi-omics datasets, including RNAseq, proteomics, single-cell, spatial, imaging, etc
Strong proficiency in statistical modeling, machine learning and integrative data analysis
Excellent programming skills in R and/or Python; experience with cloud computing environments
Ability to work independently, manage priorities across programs, and influence program strategy through data-driven insights
Strong communication and collaboration skills, with experience working in matrixed, cross-functional teams
Preferred
Experience in pulmonary disease, fibrosis, inflammation, immunology and/or cardiovascular biology
Demonstrated track record of peer-reviewed publications and conference presentations
Formal training or strong background in statistics
Benefits
Medical, dental and vision insurance
401(k) and 401(k) matching
Long-term incentive plan
Disability plan
Vacation pay
Sick time
Holiday pay
Work, personal and family time off in accordance with the terms of the applicable plans
Company
Gossamer Bio
Gossamer Bio is a biopharmaceutical company focused on the discovery and development of novel and differentiated therapeutic products.
51-200 employees
H1B Sponsorship
Gossamer Bio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2024 (2)
2023 (1)
2021 (4)
Funding
Current Stage
Public CompanyTotal Funding
$812MKey Investors
MidCap FinancialHillhouse Investment
2023-07-20Post Ipo Equity· $212M
2022-07-13Post Ipo Equity· $120M
2019-05-02Post Ipo Debt· $150M
Leadership Team
Faheem Hasnain
Founder, CEO and Chairman
Bryan Giraudo
Chief Financial Officer
Recent News
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2025-11-14
2025-11-08
2025-11-08
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