Eli Lilly and Company · 1 day ago
Scientific/Sr Scientific Lead, Bioconjugation
Louisville, CO
Full-time
Onsite
Senior Level, Lead/Staff
$138K/yr - $224K/yr
2+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, dedicated to discovering and delivering life-changing medicines. They are seeking a Scientific Lead or Senior Scientific Lead in Chemistry/Biochemistry to support their biologics and ADC portfolio by providing scientific leadership in developing bioconjugation technologies and improving ADC performance.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Prepare, purify, and characterize the high-quality antibody-conjugates (ADCs, ARCs, DACs etc.) with a high degree of independence in support of discovery and development of programs
Work with the linker-technology and medicinal chemistry teams to design and optimize the linker-payload and its bioconjugation chemistry
Apply organic and bioconjugation chemistry principles to guide linker-payload SAR and improve stability, potency, and developability
Implement state of the art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilizing novel chemistries to generate bioconjugates
Develop purification strategies (up to 200 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration
Perform comprehensive ADC characterization using UV-Vis, SEC, HIC, RP-HPLC, IEX, cIEF, and LC-MS
Engage with multidisciplinary teams across chemistry, biology, pharmacology, and CMC to design and interpret experiments
Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents
Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences
Demonstrated record of scientific accomplishments and publications
Present periodic updates and reports to management team
Contribute to the long-term strategies for innovative solutions and intellectual property for securing FTO for Lilly
Maintain a safe, pleasant, and efficient working environment
Qualification
Required
PhD in chemistry, biochemistry, or other related scientific discipline
Minimum 2-4+ years of independent, hands-on laboratory experience in an industrial or equivalent research setting (including post doc experience)
Preferred
Experience with protein purification systems is preferred with hands-on experience and proficiency working with AKTA FPLCs
Deep expertise in bioconjugation technologies and experience working with high-potency payloads
Proven ability to collaborate effectively with small-molecule and biologics project teams to drive rapid scientific progress
Track record of scientific accomplishment, including publications, patents, or significant internal contributions
Excellent written and verbal communication skills, with the ability to clearly convey complex scientific concepts
Attention to detail, and ability to manage multiple priorities in a dynamic environment
Self-motivated, enthusiastic, and continuously focused on improving scientific rigor, efficiency, and impact
Benefits
Company bonus
Company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
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reference. (Data Powered by US Department of Labor)
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2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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