Brigham and Women's Hospital · 14 hours ago
Postdoctoral Research Associate with human iPSC-derived brain organoid expertise
Boston, MA
Full-time
Onsite
Senior LevelBrigham and Women's Hospital is an internationally renowned leader in medical research, patient care, and education. The Synaptic and Network Development group is seeking a Postdoctoral Research Associate with expertise in deriving neuronal organoid cultures from human iPSCs and CRISPR gene editing technologies to investigate the impact of genetic changes in Rett syndrome on neural networks and seizures during early development.
Health CareMedical
Hiring Manager
Susanna Mierau, MD, DPhil
Responsibilities
Lead expansion and quality control checks for human induced pluripotent stem cells (iPSCs) from patients with autism or related neurodevelopmental disorders
Lead generation and maintenance of human brain organoids from patient-derived iPSCs in our laboratory
Perform molecular and immunohistochemical procedures to characterize and validate models
Work closely with team members to perform microelectrode array (MEA) recordings and analyze network activity in human brain organoids
Work closely with team members in our interdisciplinary collaborations on the development and application of methods for human organoids, network recordings and network analysis
Ensure validity and reliability of all data collected and analyzed
Keep excellent records of experiments, undertake thorough data analysis and make active contributions to the laboratory research environment
Write regular internal reports as agreed and draft and/or contribute to reports for submission to research sponsors
Prepare and present findings at internal group meetings
Draft publications and/or presentations for scientific journals/conferences
Contribute to research grant applications
Provide guidance to staff and students, including training to students and/or other trainees
Be an active team member and set positive examples for other team members
Contribute and lead administrative tasks related to research and teaching goals
Maintain a safe workplace and follow all lab and hospital practices and procedures
Any other duties commensurate with the post as directed by the PIs
Qualification
Required
PhD degree (or about to be awarded at PhD) in one of the following fields: neuroscience, physiology, stem cell biology, molecular or cellular biology, or bioengineering
A PhD in a relevant field
Research expertise sufficient to work independently
Generation and maintenance of human iPSC-derived brain organoids
Ability to work effectively and collaboratively with other group members
Superior written and verbal communication skills for working collaboratively, including communicating progress and challenges to PIs
Rigorous scientific skills for acquiring, validating, analyzing and presenting data
Excellent time and project management skills
Ability to make independent decisions and solve routine problems encountered in research projects
Meticulous record keeping for both experimental procedures and for analysis
Willingness to adjust working hours in accordance with experimental demands and as necessary for project goals
Generosity of spirit and willingness to share and help develop skills in others
Preferred
Research expertise in CRISPR and/or other gene editing technologies for human iPSCs or embryonic stem cells (ESCs)
Research experience in neurophysiology (i.e., microelectrode array recordings and/or whole-cell patch clamp technique)
Research experience in computational analysis of network activity
Company
Brigham and Women's Hospital
Brigham and Women's Hospital is an academic medical center based in Boston, Massachusetts.
Founded in 1986
10001+ employees
H1B Sponsorship
Brigham and Women's Hospital has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (219)
2024 (174)
2023 (202)
2022 (220)
2021 (137)
2020 (157)
Funding
Current Stage
Late StageTotal Funding
$22.15MKey Investors
American Medical AssociationThe Leona M. and Harry B. Helmsley Charitable TrustMassachusetts Life Sciences Center
2023-06-21Grant
2022-06-30Grant· $16M
2021-01-08Grant· $0.4M
Leadership Team
Caroline Fox
Associate Professor (Part Time), Medicine
David Silbersweig
Chairman Emeritus
Recent News
2026-01-13
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