ParcelBio · 3 hours ago
Sr. Research Associate/Associate Scientist– mRNA Sciences (in SF, CA)
San Francisco, CA
Full-time
Onsite
Senior Level
$90K/yr - $120K/yrParcelBio is searching for a highly motivated, intellectually curious scientist to help develop next-generation mRNA medicines. The role involves designing, producing, and characterizing mRNA therapeutics, while collaborating with an interdisciplinary team to advance programs to the clinic.
BiopharmaBiotechnology
Responsibilities
Lead RNA research and development projects involving mRNA production and characterization, including:
Sequence design: Work closely with the team to optimize mRNA sequence architecture
Plasmid linearization: Generate linearized IVT plasmid templates for both large- scale and screening-scale mRNA production. Optimize purification of large-scale plasmid linearization
Large-scale mRNA production: Optimize IVT reaction conditions and purification processes to generate high-quality mRNA for downstream applications
Production of mRNA screening libraries: Generate mRNA libraries for in cellulo assays. Develop and optimize high-throughput approaches for arrayed and pooled screening
Quality Control of mRNA: Perform mRNA characterization assays including dsRNA ELISA and RNA TapeStation. Onboard new analytical assays as needed
Work collaboratively and proactively with team members of diverse disciplines
Solicit feedback and come up with new and creative ideas
Manage time efficiently to simultaneously move multiple projects forward
Stay up-to-date on relevant literature and company developments
Work dynamically in a fast-paced startup environment
Qualification
Required
Strong foundation in nucleic acid molecular biology
Experience in RNA research and development projects involving mRNA production and characterization
Ability to optimize mRNA sequence architecture
Experience generating linearized IVT plasmid templates for large-scale and screening-scale mRNA production
Ability to optimize purification of large-scale plasmid linearization
Experience optimizing IVT reaction conditions and purification processes to generate high-quality mRNA
Experience generating mRNA libraries for in cellulo assays
Ability to develop and optimize high-throughput approaches for arrayed and pooled screening
Experience performing mRNA characterization assays including dsRNA ELISA and RNA TapeStation
Ability to onboard new analytical assays as needed
Strong collaboration skills to work with team members of diverse disciplines
Ability to solicit feedback and generate new and creative ideas
Strong time management skills to move multiple projects forward simultaneously
Ability to stay up-to-date on relevant literature and company developments
Ability to work dynamically in a fast-paced startup environment
Company
ParcelBio
ParcelBio is a company that creating a programmable method for safely and precisely delivering mRNA to many cell types in the body.
Founded in 2023
2-10 employees
Funding
Current Stage
Early StageTotal Funding
$0.5MKey Investors
Alumni VenturesY Combinator
2024-05-09Seed
2024-02-14Pre Seed· $0.5M
Recent News
SBXi
2025-05-16
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