BigHat Biosciences · 16 hours ago
Scientist/Senior Scientist, Display Technologies
San Mateo, CA
Full-time
Onsite
Mid, Senior Level
$145K/yr - $187K/yr
3+ years expBigHat Biosciences is seeking a self-motivated Scientist or Senior Scientist to join the Display Technologies team. This role involves expanding the company's ability to discover and engineer next-generation antibodies while generating high-quality data to enhance machine learning models using display technologies.
Artificial Intelligence (AI)BiotechnologyMedicalTherapeutics
Responsibilities
Conceive and lead R&D projects to advance display technologies at BigHat
Design antibody libraries to discover and optimize antibodies for affinity, cross-reactivity, stability, and function across diverse formats such as VHH, scFv, and Fab
Construct and QC phage and yeast display libraries of diverse antibody formats to use for in vitro selections (PCR, molecular cloning, electroporations)
Perform phage and yeast display selections using naive and affinity maturation libraries to discover and/or engineer novel next-generation antibodies for diverse therapeutic properties, including co-selection for multiple key attributes
Express, purify, and characterize display-derived molecules using a suite of assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others
Analyze results from display selections to guide next steps and future experiments
Collaborate with BigHat’s Data Science and Machine Learning teams to facilitate data transfer and analysis to further bolster library design and machine learning model training
Present experimental plans and results during regular meetings with manager and science teams
Qualification
Required
PhD with 3+ years of experience
Extensive experience with phage and yeast display workflows for antibody engineering
Experience with general molecular biology tools (PCR, Molecular Cloning, Mutagenesis) and developing/executing antibody binding assays
Effective time management and excellent written and verbal communication skills driving an ability to plan and deliver diverse technical projects simultaneously in a dynamic start-up environment
Strong record keeping skills using LIMS and electronic notebooks
Excited to work with diverse, cross functional teams to onboard new assays and disseminate results
Preferred
Previous experience with other display modalities (ribosome, mRNA, mammalian)
NGS prep/analysis of display campaigns
Experience using automation for high-throughput assay development
Benefits
Bonus
Options
Benefits
Company
BigHat Biosciences
BigHat Biosciences is a protein therapeutics company that develops an antibody design platform guided by artificial intelligence.
51-200 employees
H1B Sponsorship
BigHat Biosciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (1)
2023 (2)
Funding
Current Stage
Growth StageTotal Funding
$99.3MKey Investors
S32Andreessen HorowitzNational Institute of Standards and Technology
2022-07-20Series B· $75M
2021-02-10Series A· $19M
2020-10-01Grant
Leadership Team
Peyton Greenside
CEO
Recent News
bighatbio.com
2026-01-14
Andreessen Horowitz
2026-01-14
thesaasnews.com
2026-01-14
Company data provided by crunchbase