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Wyss Institute at Harvard University · 17 hours ago

Principal Scientist

Boston, MA

Full-time

Onsite

Lead/Staff

12+ years exp

The Wyss Institute at Harvard University is dedicated to transforming healthcare and the environment through innovative technologies. As a Principal Scientist, you will lead multidisciplinary teams in translational science initiatives, oversee research projects, and collaborate with industry partners to drive therapeutic and diagnostic innovations.

Biotechnology

No H1B

Responsibilities

Directs multiple projects that includes both academic and staff employees, industry sponsors, industry co-development partners, state and federal funding and academic collaborations

Guide assay development, molecular or cellular characterization, in vivo studies, and data interpretation to demonstrate feasibility and accelerate technology maturation

Drive translational de-risking by shaping key studies, identifying scientific opportunities, and aligning research efforts with program goals

Collaborate with internal and external partners on experimental execution, analytical characterization, and cross-functional scientific strategy

Partner with intellectual property teams to develop novel and impactful patent filings

Apply core Artzi Lab technologies, tools, and scientific approaches, and help integrate them into broader translational strategy

Manage and mentor a team of post-doctoral students, graduate students, research assistants, and less experienced scientists providing guidance across experimental, and translational domains

Responsibilities include: professional development and mentoring, managing, evaluating performance, advocating and motivating

Lead cross-functional project teams and ensure that program milestones are met with scientific rigor and strategic clarity

Build strong relationships with faculty, clinicians, collaborators, and business development professionals to advance program goals

Help forge partnerships with clinicians across Harvard-affiliated hospitals and support integration of patient-derived insights into research and development

Develop and refine translational strategies that incorporate scientific, computational, regulatory, and commercial considerations

Engage with industry partners, clinical collaborators, and philanthropic organizations to position technologies for successful translation

Participate in building collaborative opportunities that bring new expertise, datasets, or analytical capabilities into Wyss programs

Communicate program updates, risks, and strategic recommendations to senior Wyss leadership and stakeholders

Engage with partnering hospitals to leverage patient data and clinical needs to inform scientific strategy

Contribute to grant writing and help build relationships with external partners, including companies and foundations

Conduct experiments and studies that support ongoing research in the Artzi Lab. These could include formulation/nanoparticle preparation and related characterization as well in vitro and cell-based experiments, and in vivo and ex vivo studies including biomarker assays

Conduct data analysis on all experiments performed and communicate data/results to the larger team

Produce high-quality scientific documents, including study protocols, analyses, and reports

Support safe and efficient lab operations, recommend equipment purchases, and manage supply procurement as needed

Qualification

Translational researchTherapeutic developmentMolecular biologyCellular biologyAssay developmentVivo studiesComputational analysisBiologics engineeringDrug discoveryStrategic communicationTeam leadershipMentoringTechnical writing

Required

Master's degree in Biology, Bioengineering, Biomedical Science, Molecular Biology, Immunology, Computational Biology, or a related field

12 years of experience in translational research, therapeutic or diagnostic development, or related scientific leadership roles; Education may count towards experience

Proven track record leading complex scientific programs and advancing technologies toward translational or commercial milestones

Demonstrated ability to manage and mentor scientific teams across experimental and/or computational disciplines

Strong foundation in molecular or cellular biology, assay development, in vivo studies, analytical characterization, or related areas relevant to translational science

Experience with computational analysis, biologics engineering, biomolecular assay development, or translational evaluation of emerging technologies

Ability to integrate diverse scientific approaches—experimental and computational—to inform program strategy

Strong record of working with external partners to shape program direction and support high-impact collaborations

Excellent written and verbal communication skills, including technical writing, strategic communication, and presenting to senior audiences

Demonstrated success in generating impactful intellectual property and contributing to commercialization efforts

Preferred

PhD strongly preferred in Biology, Bioengineering, Biomedical Science, Molecular Biology, Immunology, Computational Biology or related field

Full-time post graduate industry experience with a focus on product development is preferred

Knowledge and experience in oncology and immunology preferred, as is drug discovery experience

Familiarity with multi-omics data, imaging analysis, or predictive modeling is beneficial but not required

Experience in drug delivery and development of nucleic acid therapeutics is strongly preferred

Benefits

Generous paid time off including parental leave

Medical, dental, and vision health insurance coverage starting on day one

Retirement plans with university contributions

Wellbeing and mental health resources

Support for families and caregivers

Professional development opportunities including tuition assistance and reimbursement

Commuter benefits, discounts and campus perks

Company

Wyss Institute at Harvard University

The Wyss Institute at Harvard University is a nonprofit research organization dedicated to translating groundbreaking discoveries from the lab into real-world solutions for human and planetary health.

Founded in 2005

Boston, MA, US

201-500 employees