AIRNA · 1 day ago
Principal Scientist/Associate Director, Clinical Biomarkers
Cambridge, MA
Full-time
Hybrid
Lead/Staff, Director/Executive
$210K/yr - $280K/yr
8+ years expAIRNA is a biotechnology company with a mission to be the leading RNA editing company delivering precision therapies to patients with rare and common diseases. They are seeking a dynamic and experienced Principal Scientist/Associate Director, Clinical Biomarkers to design and execute biomarker strategies for clinical development of oligonucleotide-based therapeutics.
BiotechnologyHealth CareMedical
Responsibilities
Lead the development and execution of biomarker strategies for clinical programs, with a focus on mechanism-of-action, pharmacokinetic and pharmacodynamic biomarkers, and patient stratification markers
Design and oversee the development, qualification/validation, and implementation of fit-for-purpose biomarker assays (e.g., ELISA, LC-MS/MS, immunoassays, NGS, etc.) in alignment with regulatory and clinical timelines
Apply multi-omics approaches (proteomics, metabolomics, transcriptomics) to uncover disease biology and drug response signals that inform clinical decision-making
Partner closely with Clinical Development, Bioinformatics, Regulatory, and external CROs to ensure high-quality data generation and integration
Serve as the scientific lead for biomarker-related activities in clinical trials, including protocol development, sample collection plans, and data interpretation
Collaborate with Discovery, Preclinical, and Regulatory to ensure continuity of biomarker strategy throughout all phases of development
Maintain awareness of emerging technologies and regulatory guidance in the biomarker space
Represent the company in external collaborations, scientific meetings, and regulatory interactions as needed
Qualification
Required
PhD in Molecular Biology, Biochemistry, Pharmacology, or related field with 8+ years of industry experience in translational medicine, biomarker development, or related function
Proven track record of biomarker leadership in clinical-stage therapeutic programs, ideally in the context of oligonucleotide therapeutics
Deep hands-on experience in proteomics and metabolomics, including data interpretation and technology selection
Strong assay development and validation experience, including managing external vendors and CROs
Demonstrated experience with central lab management and clinical sample management
Demonstrated experience translating preclinical insights into clinical biomarker strategies and endpoints
Strategic thinker with excellent problem-solving skills and the ability to operate effectively in a fast-paced, matrixed environment
Outstanding communication and collaboration skills with a demonstrated ability to lead cross-functional initiatives
Company
AIRNA
AIRNA develops RNA editing technologies to create medicines for various diseases.
11-50 employees
H1B Sponsorship
AIRNA has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2023 (2)
2022 (2)
Funding
Current Stage
Growth StageTotal Funding
$245MKey Investors
Forbion Capital PartnersARCH Venture Partners
2025-04-01Series B· $155M
2024-07-31Series A· $60M
2023-09-19Series A· $30M
Leadership Team
Kris Elverum
President and Chief Executive Officer
Jin Billy Li
Co-Founder
Recent News
2025-10-04
Research & Development World
2025-09-25
Company data provided by crunchbase