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Arrowhead Pharmaceuticals · 17 hours ago

Director, Pharmacometrics & Clinical Pharmacology

San Diego, CA

Full-time

Onsite

Director/Executive

$220K/yr - $245K/yr

8+ years exp

Arrowhead Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing innovative drugs for diseases with a genetic basis. The Director of Pharmacometrics and Clinical Pharmacology will provide strategic and scientific leadership across clinical development programs, ensuring rigorous dosing strategies and alignment with regulatory expectations.

BiotechnologyHealth CareNanotechnologyPharmaceutical

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Provide leadership and subject matter expertise in pharmacometrics and clinical pharmacology across Arrowhead’s development portfolio

Contribute to global regulatory submissions, including marketing applications for siRNA-based therapeutics

Design and support clinical trial protocols, including dose selection and optimization strategies

Author and review clinical pharmacology sections of Investigational Brochures (IBs), Clinical Study Reports (CSRs), and other regulatory documents

Conduct and oversee analysis of clinical and translational PK/PD data, including population PK/PD modeling

Communicate analysis results, interpretation, and strategic recommendations to project teams in a timely and effective manner

Develop clinical pharmacology plans and propose dosing strategies across development stages

Maintain current knowledge of clinical pharmacology literature, regulatory guidance, and best practices relevant to oligonucleotide and RNAi therapeutics

Qualification

PharmacokineticsPharmacologyPopulation PK/PD modelingClinical trial designRegulatory submissionsData analysisLeadershipCross-functional collaborationCommunication skills

Required

Doctoral degree (PhD, PharmD) in pharmacokinetics, pharmacology, pharmaceutical sciences, or a related discipline

8 years of post-degree experience in the pharmaceutical or biotechnology industry in pharmacometrics or clinical pharmacology roles

Demonstrated expertise in population PK/PD modeling, with proficiency in standard software platforms such as NONMEM

Experience supporting regulatory submissions and interacting with cross-functional development teams

Preferred

Familiarity with PBPK/PD or quantitative systems pharmacology (QSP) modeling

Benefits

Competitive salaries

Excellent benefit package

Company

Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals is a biotechnology company that focuses on the development of medicine to treat diseases with a genetic origin.

Founded in 1989

Pasadena, California, USA

501-1000 employees

http://arrowheadpharma.com/

H1B Sponsorship

Arrowhead Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (4)

2024 (5)

2023 (1)

2022 (5)

2020 (1)

Funding

Current Stage

Public Company

Total Funding

$2.45B

Key Investors

Sarepta TherapeuticsSixth StreetSilence Therapeutics

2026-01-07Post Ipo Equity· $200M

2026-01-07Post Ipo Debt· $625M

2024-11-26Post Ipo Equity· $325M

Leadership Team

Christopher Anzalone

President and Chief Executive Officer

Recent News

BioSpace

After Mortality-Marred Year, Sarepta Looks Ahead to Catalyst-Rich 2026

2026-01-14

FiercePharma

2025 drug approvals: Despite FDA tumult and macro uncertainty, biopharma scored with 55 new products

2026-01-09

TradingView

Arrowhead Pharmaceuticals Offers 3,100,776 Shares At $64.50 Per Share

2026-01-08

Company data provided by crunchbase