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AstraZeneca · 20 hours ago

Associate Scientist IV, Biomarker Development

US - New Haven - CT

Full-time

Onsite

Senior Level

5+ years exp

AstraZeneca's Alexion division is dedicated to advancing medicine for patients with rare diseases. The Associate Scientist IV in Biomarker Development will contribute to research and clinical development programs by identifying biomarkers, developing innovative platforms, and collaborating with cross-functional teams to drive drug development efforts.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Actively contribute to the biomarker support of multiple programs in multiple therapeutic areas through literature reviews and database searches to identify potential new biomarkers of disease activity and/or therapeutic efficacy (mechanism of disease, response/pharmacodynamic, predictive, exploratory, etc)

Collaborate with colleagues and independently evaluate new technologies, design, develop, troubleshoot novel sample testing protocols, and follow existing protocols for the detection, quantitation and/or functional activity of target biomarkers in complex biological matrices including proteins and nucleic acids

Develop and perform in vitro binding or functional assays using purified reagents, primary cells or cell lines (human, murine and/or primate) to evaluate target levels, functional activity or mechanism of action of candidate therapeutics

Lead or support biomarker assay validation for clinical sample analysis and interact with cross-functional sub-teams and CROs supporting technical, operational and troubleshooting aspects of assays

Provide support as required to other Translational Biomarker Research team members and groups within Research

Analyze, summarize and present data in individual, group meetings, conferences or in written summary documents

Qualification

BiochemistryCell BiologyProtein AssaysAssay ValidationClinical DevelopmentData AnalysisExperimental DesignMicrosoft OfficeData Graphing SoftwareCommunication SkillsOrganizational SkillsInterpersonal Skills

Required

5+ years of pharmaceutical industry experience

BA/BS in biochemistry or related field with 10+ years of total experience or a MS in biochemistry or related field with 7+ years of total experience

Solid understanding of the principles of cell biology, disease pathogenesis and strategies for therapeutic intervention and application of these principles for understanding cellular responses and disease pathogenesis

Proven track record of technical proficiency, creativity in experimental design and independent, critical thinking to identify novel methods or solutions/troubleshooting

Ability to independently design, execute, analyze, and interpret experiments, as well as troubleshoot to overcome technical challenges in a high-tech, fast-paced environment

Familiarity with clinical stage development programs, protocols, sample handling, data analysis and management according to GCPs

Proven experience with protein and cell-based assays, examples include ELISA, MSD, Luminex, immunoprecipitation, proteomics (e.g. Olink), and/or flow cytometry

Hands-on experience developing and optimizing single and multiplex assays; experience with assay validation in a GxP environment

Excellent communication, record keeping and organizational skills and familiarity with electronic lab notebook procedures

Strong interpersonal skills and ability to work well with cross-functional members

Experience with Microsoft Office (e.g., Word, Excel, PowerPoint) and data graphing software (e.g. Graphpad Prism) for report writing, presentation and data analysis

Preferred

Experience with exosome isolation and analysis

Experience with nucleic acid purification and methodologies such as RT-PCR, RNAseq, microRNA characterization and data analysis and interpretation

Experience with SIMOA, spatial biology platforms (e.g., Nanostring CosMx)

Experience with mammalian cell culture and aseptic techniques

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2021 (2)

2020 (11)