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City of Hope · 12 hours ago

Staff Scientist - Hematologic Malignancies

Duarte, CA

Full-time

Onsite

Senior Level, Lead/Staff

3+ years exp

City of Hope is a leading research institution dedicated to innovative approaches in predicting, preventing, and curing diseases. The Staff Scientist will focus on translational research in hematologic malignancies, leading experiments and collaborating with clinical and research teams to advance studies with diagnostic and therapeutic impact.

AssociationEducationHealth Care

Comp. & Benefits

Responsibilities

Design and execute experiments involving genetically engineered mouse models, patient-derived samples, and molecular assays, including DNA/RNA sequencing, immunohistochemistry, and flow cytometry

Develop and optimize laboratory protocols for studying disease mechanisms, biomarker discovery, and diagnostic refinement in hematologic malignancies

Analyze and interpret experimental data using appropriate computational tools and collaborate with bioinformatics staff when necessary

Troubleshoot laboratory equipment (e.g., flow cytometers, sequencers) and coordinate routine maintenance and quality control

Work collaboratively with team members to design experiments, interpret findings, and contribute to manuscript and grant preparation

Communicate experimental results clearly to faculty, trainees, and clinical collaborators; contribute to team meetings and project planning

Provide mentorship and training to junior lab members on experimental design, execution, and data analysis

Maintain meticulous and organized records of all experiments and ensure proper documentation for data reproducibility

Adhere to institutional and laboratory safety regulations and compliance standards for working with human samples and animal models

Qualification

Hematologic malignanciesMolecular profiling techniquesFlow cytometryGenetically engineered mouse modelsData analysisImmunophenotypingGenomic profiling toolsLaboratory operations managementMentoring

Required

PhD, MD, or MD/PhD degree in a relevant biomedical field (or commensurate experience) with a minimum of 3 years of hands-on experience in a clinical or research laboratory focused on hematologic malignancies, molecular pathology, or flow cytometry

Demonstrated expertise in data analysis and immunophenotyping; experience with cell sorting is highly desirable

Proven ability to design and execute experiments using mouse models, primary human samples, and genomic profiling tools (e.g., NGS, RNA-seq)

Demonstrated leadership in mentoring junior staff and managing laboratory operations