Allergan Aesthetics, an AbbVie Company · 22 hours ago
Senior Scientist (I/II), Human Genetics Group
North Chicago, IL
Full-time
Onsite
Senior Level, Lead/Staff
$106K/yr - $202K/yr
8+ years expAbbVie is a company dedicated to discovering and delivering innovative medicines to address serious health issues. They are seeking a Senior Scientist in the Human Genetics Group to support target discovery and development efforts, contributing to studies aimed at understanding the biological mechanisms of diseases and collaborating with cross-functional teams on genomic analyses.
BeautyManufacturingPharmaceuticalWellness
Responsibilities
Lead genetics-driven target and biomarker identification across AbbVie’s therapeutic areas using cutting-edge methods and large-scale biobank datasets (e.g., FinnGen, Alliance for Genomic Discovery, UK Biobank, All *of* Us) and clinical cohort data
Design and execute innovative approaches to uncover genotype-phenotype associations through disease-focused case-control and time-to-event study designs
Identify genetic determinants influencing disease progression and patient response to treatments
Analyze polygenic risk scores (PRS) to enhance patient stratification, identify genetically defined subgroups, gain insights into disease mechanisms, and support precision medicine strategies
Assess heterogeneity in disease risk and investigate how PRS profiles are associated with differences in treatment responses
Systematically mine internal and external phenome-wide association study (PheWAS) datasets to identify novel and population-specific genetic associations
Analyze genomics data from clinical trial participants to identify response biomarkers and support reverse translation efforts
Perform and interpret post-GWAS analyses (e.g., fine mapping of GWAS loci, GWAS signal colocalization with molecular QTLs, Mendelian Randomization and others) to identify and prioritize causal genes and targets
Integrate single-cell omics and proteomics datasets with genomic and clinical data
Collaborate with therapeutic area scientists to generate therapeutic hypotheses, support novel target identification and validation through exploratory analyses, and facilitate progression through pipeline phase transitions
Lead cross-functional projects with therapeutic area leads
Qualification
Required
Bachelor's Degree or equivalent education and typically, 10-12 years of experience, Master's Degree or equivalent education and typically 8-10 years of experience, PhD and 0-4 years of experience
Fluency in programming languages such as R and Python and working in command-line on HPC clusters
Expertise in biobank scale genome-wide association studies (GWAS) and rare variant association studies (RVAS)
Hands-on experience in methods and tools such as PLINK, SAIGE, REGENIE, fastGWA, SKAT/ACAT
Hands-on experience working with different types of genotype data such as array, WGS, and imputed
Hands-on experience with electronic health records (EHR) and OMOP CDM format data
Familiarity with open-source genomics and omics resources (e.g., Open Targets, HGMD, GTEx, eQTL Catalog and others)
Preferred
Previous industry experience in pharmaceutical or biotechnology companies working with large-scale human genetic datasets
Experience in cloud genomics research environments (e.g., All of Us Researcher Workbench, UK Biobank Research Analysis Platform and FinnGen sandbox)
Strong track record of relevant scientific publications and presentations
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Company
Allergan Aesthetics, an AbbVie Company
At Allergan Aesthetics, an AbbVie company, we develop, manufacture, and market a portfolio of leading aesthetics brands and products.
1001-5000 employees
H1B Sponsorship
Allergan Aesthetics, an AbbVie Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2023 (1)
2022 (16)
2021 (14)
2020 (5)
Funding
Current Stage
Late StageLeadership Team
Nicole Mowad-Nassar
Senior Vice President, AbbVie and President, Global Allergan Aesthetics
Recent News
2025-12-04
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