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NEXI Biotech · 6 days ago

Head of Data Science, Electrophysiology Analytics (Founding Leadership)

United States

Full-time

Remote

Director/Executive

NEXI Biotech is an inception-stage neurotechnology startup pioneering next-generation human neural circuit platforms for translational drug discovery. The Head of Data Science, Electrophysiology Analytics will be responsible for defining how electrophysiological data is represented, interpreted, and validated across NEXI’s platform, serving as the technical authority for neural data interpretation and setting analytical standards.

Biotechnology

Responsibilities

Define analytical frameworks for high-density electrophysiology data, including spike-based and network-level features

Establish standards for signal preprocessing, artifact handling, normalization, and quality control

Guide interpretation of temporal dynamics, synchrony, delay, and modulation in neural circuits

Ensure analytical approaches remain biologically grounded and experimentally faithful

Lead development of functional connectivity metrics and graph-based representations of neural circuits

Define how directionality, causality, and regional organization are captured analytically

Establish approaches for comparing baseline vs perturbed network states (e.g., pharmacology, disease models)

Set expectations for reproducibility and cross-experiment comparability

Define how electrophysiological features are abstracted into digital phenotypic signatures

Guide development of consistent representations that support stratification, comparison, and longitudinal tracking

Ensure phenotypes remain interpretable and aligned with translational relevance

Oversee integration of experimental metadata (cell type, region, configuration, treatment, timepoint) into analytical outputs

Ensure physical system architecture and experimental design are reflected appropriately in analytics

Collaborate closely with biology and hardware teams to align interpretation with reality

Establish internal standards for analytics, validation, and documentation

Guide development of reference datasets and analytical benchmarks

Contribute to long-term analytics roadmap and hiring strategy

Support technical discussions with collaborators, partners, and funding agencies as appropriate

Qualification

Electrophysiology data analysisSignal processingNetwork analysisGraph theoryComputational biologyPython programmingInterdisciplinary collaborationStartup experienceClear communicationLeadership experience