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Merck · 1 day ago

Associate Principal Scientist, Drug Metabolism & Pharmacokinetics

USA - Pennsylvania - West Point

Full-time

Hybrid

Senior Level, Lead/Staff

$142K/yr - $224K/yr

5+ years exp

Merck is seeking dynamic and collaborative scientists for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Associate Principal Scientist will contribute to drug discovery and development efforts by providing an integrated understanding of DMPK properties and guiding teams on DDI strategies.

BiotechnologyHealth CareMedicalPharmaceutical

Comp. & Benefits

H1B Sponsored

Responsibilities

Working on teams of highly collaborative, cross-functional scientists to discover and develop therapeutics across various modalities

Design and interpret in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile

Assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy

Author source reports and documents in support of regulatory filings

Independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making

Qualification

DMPKPharmacokineticsPharmacodynamicsDrug MetabolismADMEDrug InteractionsPKPD ModelingLiquid Chromatography-Mass Spectrometry (LC-MS)CommunicationMentorshipProject LeadershipStrategic Thinking

Required

Bachelor's, Master's, or PhD degree in Pharmaceutical Sciences, Pharmacology, Chemistry, Biomedical Engineering, Biochemistry, Biology, Biophysics, Biostatistics, or relevant STEM fields

Bachelor's with 10+, Master's degree with 8+ or PhD with 5 + years of industry experience in a relevant field with a focus on discovery and development of therapeutics of various modalities (including small molecules, antibodies, and drug conjugates)

Strong leadership, interpersonal, communication, problem solving, and collaboration skills, while delivering results on firm deadlines

Experienced in integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, design of PK/PD and safety assessment studies, and dose justifications for preclinical and clinical studies

Experience in assessing the impact of various factors on the pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management

Experience with authoring documents in support of IB, IND, WMA filings, and responses to regulatory inquiries

Demonstrated track record as an effective collaborator on multi-disciplinary discovery and development teams