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Sino Biological, Inc. · 1 day ago

R&D Senior Scientist

Houston, TX

Full-time

Onsite

Senior Level, Lead/Staff

5+ years exp

Sino Biological, Inc. is an internationally recognized reagent supplier and contract research organization seeking an accomplished scientist to join their team as a Senior R&D Scientist. This role involves leading protein production projects and ensuring the delivery of high-quality proteins for research and therapeutic applications.

BiotechnologyHealth CareTherapeutics

No H1B

Responsibilities

Lead end-to-end protein production projects, from amino acid sequence design to purified, quality-tested product

Design and optimize molecular constructs for recombinant proteins, including antibodies and antibody-derived formats (full-length IgG, bispecific, Fab, scFv, Fc-fusions) as well as Fc- and non-Fc fusion proteins

Develop and lead critical SOPs, especially those related to sequence/construct design and molecular engineering, in coordination with upstream, downstream, and analytical teams

Assist with customized project inquiry review. Determine feasibility of protein expressions, identify areas for optimization, and draft production proposals for project managers

Advise and review upstream expression workflows in mammalian and insect systems (HEK293, CHO, Sf9), ensuring reproducibility and scalability

Lead downstream purification strategies using modern chromatography platforms (affinity, IEX, SEC) and contribute to process optimization

Develop and interpret analytical assays, including ELISA, BLI, DSF, HPLC-SEC, and related QC methods, to assess protein quality, stability, and activity

Mentor and supervise associates and junior scientists, ensuring rigorous documentation, data integrity, and efficient lab execution

Collaborate across departments to align on construct design principles, process strategies, and project execution

Perform bench work when necessary to support critical experiments, troubleshooting, or method development

Qualification

Recombinant protein productionMolecular construct designProtein purificationProtein characterization assaysChromatography platformsSOP authorshipProject managementCommunication skillsOrganizational skillsTeam collaborationFlexibility

Required

Ph.D. in Biochemistry, Molecular Biology, Biotechnology, or related field, with 5+ years of industrial experience in recombinant protein and antibody production

Proven expertise in amino acid sequence design and molecular construct development for recombinant proteins, including antibodies (full-length IgG, bispecific, Fab, scFv) and fusion proteins (Fc- and non-Fc)

Experience with protein structural and sequence analysis software

Demonstrated ability to act as a sole technical contributor and project owner

Hands-on experience with mammalian and insect cell expression systems, as well as chromatography purification (e.g., Cytiva AKTA)

Proficiency in protein characterization assays such as ELISA, BLI, DSF, HPLC-SEC, and SDS-PAGE

Strong record of SOP authorship and cross-team collaboration on technical standards

Excellent project management, organizational, and communication skills

Flexibility to work occasional early/late shifts or weekends based on project needs

Must be able to lift and move 25–50 lbs as needed

At this time, we are unable to provide visa sponsorship. Applicants must be legally authorized to work in the United States now and in the future without the need for sponsorship

Preferred

Industrial CRO/CMO experience preferred

Benefits

World-class location: Be part of the Texas Medical Center, the largest medical complex in the world, where biotech innovation thrives.

Beautiful work environment: Enjoy a brand-new, state-of-the-art facility designed for collaboration and scientific excellence.

Free onsite parking: Skip the hassle and expense of parking in the Medical Center — we’ve got you covered.

Free onsite gym: Stay active and energized with convenient access to fitness facilities right at work.

Career growth opportunities: Learn directly from industry professionals while growing your career at a global biotech company.

Supportive team culture: A welcoming, team-first workplace that values diversity, collaboration, and professional development.

Company

Sino Biological, Inc.

Sino Biological is a global leader in recombinant protein and antibody production, gene synthesis, and CRO services for life sciences research and drug development.

Founded in 2007

Beijing, Beijing, CHN

501-1000 employees