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Illumina · 17 hours ago

Engineer 1 - Process Development

US - California - San Diego

Full-time

Onsite

New Grad, Entry Level

$68K/yr - $103K/yr

0+ years exp

Illumina is a company focused on expanding access to genomic technology to promote health equity. The Engineer 1 - Process Development will be part of the Manufacturing Technology & Transfer team, responsible for developing and deploying oligonucleotide manufacturing processes while collaborating with various teams to ensure successful project execution.

BiotechnologyGeneticsHealth CareMedical

No H1B

Responsibilities

Execute feasibility and development oligonucleotide builds as necessary to support various projects timelines

Define technical requirements for manufacturing processes and new production equipment

Author procedures and instructions for new manufacturing processes and train production operators to manufacture product in a GMP environment

Troubleshoot new product and manufacturing process issues related to yield, quality and throughput

Develop understanding of CPM (critical parameter management); construct and execute controlled experiments including DOE's to optimize processes and scale; address yield/quality issues and drive implementation of solutions into a production environment to meet project goals

Analyze process test results, contribute to reports and inform technical recommendations to improve product and process quality

Work cross functionally with Product Development, Supply Chain, Manufacturing, Quality, EHS and Facilities teams to enable operations for both launch and final scale manufacturing

Ensure successful transfer of knowledge into manufacturing and the sustaining support teams

Qualification

Oligonucleotide processesProcess developmentCGMP experienceStatisticsProject managementEffective communicationOrganizational skills

Required

Experience with some and ideally all oligonucleotide processes (synthesis, cleavage/deprotection, purification, desalting, and in-process and final QC) and equipment (synthesizers, preparative HPLCs, analytical HPLCs, MSs, UV Specs, etc)

Demonstrated ability to accomplish goals while working across departments

Effective communication (both verbal and written) and organizational skills to manage competing project priorities

B.S. or M.S. in Chemistry, Biochemistry, Chemical Engineering, or equivalent, with 0-3 years of relevant industry experience in oligonucleotide manufacturing/support, process development, scale-up, and process improvement