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VitriVax · 6 days ago

Scientist, Particle Characterization

Boulder, CO

Full-time

Onsite

Mid, Senior Level

$100K/yr - $160K/yr

5+ years exp

VitriVax, Inc. is creating thermostable, single-injection vaccines using an innovative technology platform called ALTA®. The Scientist in the Particle Characterization group will develop and apply analytical methods to characterize spray dried particles and ALTA™ products, working closely with a team of scientists and engineers.

BiotechnologyMedicalMedical DeviceTherapeutics

Responsibilities

In-house subject matter expert for ALTA™ and spray dried particle characterization

Remains up to date on particle characterization techniques and manages testing by 3 parties (academic or CDMO)

Recommends/specifies equipment for purchase that has high potential to address routine characterization or QC testing of ALTA™ products and intermediates

Supports the investigation of bulk material properties and surface chemistry towards the goal of understanding product performance

Independently designs, executes and authors reports summarizing material properties of ALTA™ particles, intermediates and processes

Supports investigations of ALTA™ manufacturing processes

Works closely with Formulation Development and Particle Engineering to establish product specifications and conduct stability studies

Supports Quality Control testing to support, in-process, product release, and stability testing

Contributes toward portions of IND or BLA eCTD module 2 and 3

Adheres to Company policies and laboratory notebook and safety guidelines

Qualification

Particle size analysisSolid-state characterizationAnalytical techniquesICH guidelinesStatistical analysisInnovative mindsetPassionate about vaccinesQuality-focusedTeam player

Required

A PhD degree in Analytical Chemistry, Material Science, or related field with dissertation characterizing powder properties

An in-depth understanding of particle size analysis techniques

Experience in solid-state characterization, encompassing X-ray powder diffraction, X-ray photoelectron spectroscopy, differential scanning calorimetry, thermogravimetric analysis, among others

Experience with a variety of general analytical techniques (i.e. Karl Fisher, surface area analysis, SEM, pycnometry, ICP-MS, AAS, powder flowability and friability, etc.)

Background working with lyophilized or spray dried pharmaceutical products, particularly with proteins, lipids, and/or mRNA lyophilization is a plus

Understanding of ICH Q6, Q8, Q9, Q10, and Quality by Design

Proficient in the use of statistical analysis methods and standard office tools like Excel and Word