Sanofi · 1 day ago
Senior Scientist, Advanced Ocular In Vitro Models
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
3+ years expSanofi is an R&D-driven, AI-powered biopharma company committed to improving people’s lives. They are seeking a Senior Scientist to lead the development and application of advanced ocular in vitro models supporting their Ophthalmology pipeline, focusing on designing and optimizing models for retinal diseases and mentoring colleagues.
Health CareLife SciencePharmaceuticalTherapeutics
Responsibilities
Drive the development and integration of advanced ocular in vitro platforms to accelerate early- and late-stage ophthalmology drug discovery
Lead the evaluation and validation of differentiation protocols for iPSC-derived ocular cell types (e.g., RPE, RGCs, microglia, endothelial cells) for disease modeling and drug discovery
Integrate automation and robotics to scale workflows and improve reproducibility, including developing automated liquid handling protocols, implementing high-throughput imaging and data acquisition systems, and optimizing robotic platforms for multi-step differentiation processes
Evaluate and implement innovative technologies (co-cultures, organoids, MPS, organ-on-chip, bioprinting) to improve model complexity and translational relevance
Develop and validate assays for retinal degeneration, retinal immunology, and neuroinflammation to support mechanistic studies and therapeutic evaluation
Influence project strategies by providing scientific expertise and resource planning for team objectives
Deliver high-quality scientific presentations and documentation to support milestones and decision-making
Communicate findings through internal forums and external publications/presentations; maintain involvement in professional societies
Mentor junior scientists and foster a culture of scientific excellence and collaboration
Qualification
Required
Earned Ph.D. in a relevant scientific discipline plus 3+ years postdoctoral or industry experience
Expertise in iPSC-based 2D/3D differentiation of ocular cell types for disease modeling and drug discovery
Expertise with robotics, automated cell culture systems, and/or protocol scaling
Expertise in qPCR, -omics technologies, immunocytochemistry, and advanced imaging and analysis
Demonstrated track record of scientific contributions through publications, patents, or external presentations
Demonstrated ability to lead research project teams and drive cross-functional collaboration is essential for this role
Proven ability to operate independently and take initiative in complex, dynamic research environments, ensuring progress toward strategic objectives
Exceptional analytical and critical thinking skills with the ability to evaluate complex scientific data and develop innovative solutions to research challenges
Excellent communication and interpersonal skills; proven ability to influence and mentor
Effective resource planning and time management to meet project objectives
Preferred
Experience with CRISPR-based screening approaches for functional genomics and target validation
Proven ability to develop and optimize 3D ocular models (organoids, co-cultures, microphysiological systems)
Expertise in automating differentiation protocols for scalability and reproducibility
Demonstrated leadership in research programs relevant to ocular disease, including cross-functional collaboration and strategic planning
Experience developing and validating assays for retinal degeneration, retinal immunology, and neuroinflammation
Experience with computational and statistical analysis tools (e.g., R, Python)
Benefits
High-quality healthcare
Prevention and wellness programs
At least 14 weeks’ gender-neutral parental leave
Company
Sanofi
Sanofi is a global biopharma company focused on prescription drugs, vaccines, and treatments for chronic, rare, and infectious diseases.
10001+ employees
H1B Sponsorship
Sanofi has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (101)
2024 (68)
2023 (59)
2022 (78)
2021 (38)
2020 (38)
Funding
Current Stage
Public CompanyTotal Funding
$6.97BKey Investors
Blackstone Life SciencesEvotec
2025-10-28Post Ipo Debt· $3B
2025-06-17Post Ipo Debt· $1.74B
2025-03-05Post Ipo Debt· $1.59B
Leadership Team
Paul Hudson
Chief Executive Officer
Francois-Xavier Roger
Chief Financial Officer
Recent News
2026-01-06
BioWorld Financial Watch
2026-01-06
2026-01-06
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