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Fapon · 13 hours ago

Senior/Principal Research Associate, LNP Discovery/PD

Boston, MA

Full-time

Onsite

Senior Level, Lead/Staff

3+ years exp

Fapon is an innovative biotechnology startup focused on advancing RNA therapeutics. The Senior/Principal Research Associate will lead LNP formulation process development for RNA delivery, optimizing formulations and collaborating with cross-functional teams to support drug development efforts.

BiotechnologyHealth CareManufacturingMedical

Responsibilities

Establish, execute and document protocols for preparation and characterization of targeted LNP formulations with nucleic acid cargo for in vitro and in vivo studies

Design and execute DOE-driven studies for LNP composition, mixing parameters and process optimization to improve formulation quality, stability, delivery efficiency and functional activity

Develop cell and molecular biology assays to assess the delivery efficiency of RNA cargo in mammalian primary cells to facilitate development of therapeutics drugs pipelines

Assist in the buildout of formulation and analytical capabilities with focus on delivery with nanoparticle technology, lyophilization and process development for scale up/production

Contribute to patent applications related to the delivery technology

Support technology transfer to CDMOs and Industry Partners

Foster collaborative relationships across the team and company and engage in a positive and exciting work environment

Contribute to hiring, training, and collaborating with scientists (as needed) to formulate, characterize, develop, and support assessment of efficacy

Plan and coordinate animal studies with in vivo team

Author technical documents, including SOPs for formulation processes and analytical methods, maintain diligent records and demonstrate proficiency in scientific communication

Support high-quality documentations to support regulatory filings

Qualification

LNP formulationProcess developmentAnalytical assaysLyophilization protocolsCellMolecular biologyScientific communicationRecord keepingCollaboration

Required

BS/MS in chemical engineering, chemistry, pharmaceutical sciences, or related field, preferably with industry experience of 2-5 years for MS or 5-8 years for BS candidates

Strong track record of productivity in nanoparticle research with an understanding of key challenges in nanoparticle/formulation scale-up and translation

Prior experience in developing lyophilization protocols for nanoparticle formulation, and stability testing is a plus

Technical proficiency with LNP formulation of RNA and analytical assays for particle characterization

Technical proficiency in developing cell and molecular biology assays to support drug product development

A minimum of 3-4 years of experience working with lipid nanoparticles for RNA delivery in any capacity

Preferred

Demonstrated capability in LNP formulation for nucleic acid delivery is must

LNP process development and scale-up experience is desired

Experience with tissue-specific targeted delivery of LNP-nucleic acid formulation is a plus

Demonstrated ability to present complex technical topics to a wide range of audiences with varying technical depth

Demonstrated proficiency in record keeping and documentations to support SOP generation, technology transfer and preferably regulatory filings

Benefits

Financial security through competitive compensation, incentives, and retirement plan

Health care and well-being programs including competitive medical, dental, vision & medical benefits

Generous paid time off including vacation, sick time, holidays, and winter shutdown

401(k) retirement savings with a generous company match

Commuter benefits

Other comprehensive voluntary benefits include but are not limited to pet insurance, life insurance, employee assistance program (EAP), discount programs, and many more

We continue to optimize our benefits & wellness programs as we grow our organization to make sure they meet our diverse workforce needs

The stability of a startup backed by a company with a record of strong financial performance year over year