Promega Corporation · 12 hours ago
Sr Research Scientist 1
Madison, WI
Full-time
Onsite
Senior Level
6+ years expPromega Corporation is focused on providing tailored R&D solutions for drug discovery and development. The Sr Research Scientist 1 will lead the design and optimization of cell-based screening assays, ensuring their successful implementation in client-focused projects while mentoring junior scientists and managing multiple projects.
JournalismLife ScienceManufacturing
Responsibilities
Develop, validate and execute cell-based assays for screening customer-provided compounds across a range of biological targets, including kinase, TPD and biologics-relevant targets
Lead the development, validation and implementation of new and emerging cell-based screening technologies and target engagement assay platforms (including proprietary platforms developed within Promega) for hit finding against client targets and libraries
Optimize and implement automation platforms for performing cell-based assay screens (including target engagement and follow-up assays), ensuring efficiency, reproducibility and scalability for small and large library campaigns. Leverage artificial intelligence and advanced digital tools to accelerate assay development, optimize automation workflows, enhance data analysis, and improve scientific and operational efficiency across screening programs. Leverage artificial intelligence and advanced digital tools to accelerate assay development, optimize automation workflows, enhance data analysis, and improve scientific and operational efficiency across screening programs
Identify and resolve assay-related challenges, including complex issues encountered during high-throughput execution, providing clear recommendations for improvements to internal teams and customers
Partner closely with R&D to transfer new assays and technologies into TRS Screening Services, including cell-based target engagement workflows (e.g., NanoBRET TE, thermal shift-style assays), TPD and PPI assays, ensuring smooth transition and scalability from feasibility studies to routine service offerings
Mentor and guide team members (including Research Scientist and Research Scientist II roles) in cell-based assay development, screening techniques, automation best practices and data interpretation
Plan, manage and troubleshoot assay projects to ensure successful execution, data quality and adherence to agreed timelines and deliverables
Apply expertise in cell-based screening to refine methodologies, improve assay robustness and support the integration of new readouts or formats as needed for client programs
Assess and enhance existing and novel assay technologies for seamless integration with automation platforms and data systems, with attention to efficiency, scalability and data quality
Perform hands-on bench work as needed to support assay development, optimization, troubleshooting and critical experimental runs
Ensure compliance with ethical, legal and regulatory standards relevant to cell-based research and client-specific requirements
Promote an inclusive and respectful workplace environment through effective communication and collaboration
Demonstrate inclusion through words and actions and be accountable for a safe workspace, acting with kindness, curiosity and respect for others
Embrace and be open to incorporating Promega’s Emotional & Social Intelligence (ESI) core principles in daily work
Qualification
Required
BS degree in a scientific discipline with 12+ years post-graduate experience in cell-based assay development
MS degree in a scientific discipline with 6+ years post-graduate experience in cell-based assay development
PhD degree in a scientific discipline with 0-3 years post-graduate experience, preferably in an industrial research and/or development environment, with a focus on cell-based assay screening
Demonstrated proficiency in digital tools and technology, including Microsoft applications and mobile platforms, with the ability to adapt and leverage emerging technologies, such as artificial intelligence, to improve efficiency, automation, and collaboration
Preferred
Experience with high-throughput screening (HTS) and automation of cell-based assays
Demonstrated experience in technology transfer of complex assays from R&D/feasibility into production or service environments, including documentation, training and ongoing support for scalable execution
Experience with NanoBRET, thermal shift or other cell-based target engagement assays, or related biophysical methods for monitoring compound-induced protein stabilization or engagement
Strong publication or project track record in cell-based screening, assay development or target engagement / mechanistic studies
Proficiency in data analysis software and statistical tools for assay optimization, QC and interpretation of screening results
Experience utilizing laboratory automation platforms for cell-based assays, including: Operation and programming of liquid handling robots
Integration of automation solutions for multi-step assays
Troubleshooting and optimizing automated workflows for assay reproducibility and efficiency
Familiarity with LIMS and data management systems for automated screening
Collaboration with automation and data teams to enhance laboratory throughput and efficiency
Prior experience in a fee-for-service or CRO-like environment and direct interaction with external clients
Company
Promega Corporation
At Promega Corporation, creativity and connection drive discovery and innovation.
1001-5000 employees
H1B Sponsorship
Promega Corporation has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (5)
2024 (3)
2023 (3)
2022 (1)
2020 (2)
Funding
Current Stage
Late StageTotal Funding
unknown1984-12-01Series Unknown
Leadership Team
W
William Linton
CEO and Chairman
Recent News
Startup and Tech News - Madison Startups
2025-12-24
2025-12-15
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