Oxford BioTherapeutics · 3 weeks ago
Senior/Principal Scientist, Protein-Biologic Discovery
San Jose, CA
Full-time
Onsite
Senior Level
5+ years expOxford BioTherapeutics is a dynamic, rapidly-growing biotechnology company focused on oncology therapies. The Senior/Principal Scientist will lead the development of antigen antibodies against novel targets, overseeing various aspects of early discovery and validation research.
BiotechnologyGeneticsHealth CareHealth DiagnosticsTherapeutics
Responsibilities
Serve as a key contributor to the discovery and development of antibody therapeutics for oncology and immune oncology for novel targets
Design and implement recombinant protein and bi- and multi-specific antibody discovery plans (immunogen design, assay development, screening, and functional characterization methods) and oversee the executions
Support biologic discovery through different platforms of protein and antibody discoveries
Oversee various target projects to execute protein production and antibody discovery/optimization in various platforms
Generate target over-expressing cell lines for antibody discovery work
Develop strategies to express, purify, and analyze proteins for novel tumor targets expressed in mammalian cells
Extensive experience in human protein and antibody purifications using a variety of chromatographic techniques with hands-on experience using and maintaining AKTA FPLC and Agilent HPLC & UPLC
Characterization of antibodies including binding affinity and binding kinetics through Octet/Biacore, epitope binning/mapping, and functional assays
Analyze data, interpret results, identify problems, and develop trouble-shooting plans
Participate in the transfer of processes, technology, and assays to/from internal and external collaborators and outside vendors
Qualification
Required
PhD. in biological sciences or related fields with 5+ years of post-Ph.D., or MS with 10+ years of experience in biopharma industry or closely related scientific discipline, preferably in a fast-paced startup environment
Experience in molecular biology or/and biochemistry, including gene manipulation, subcloning, expression vector modifications, and protein expressions in HEK & CHO cell systems
Extensive experience in human protein and antibody purifications using a variety of chromatographic techniques with hands-on experience using and maintaining AKTA FPLC and Agilent HPLC & UPLC
Characterization of antibodies including binding affinity and binding kinetics through Octet/Biacore, epitope binning/mapping, and functional assays
Analyze data, interpret results, identify problems, and develop trouble-shooting plans
Participate in the transfer of processes, technology, and assays to/from internal and external collaborators and outside vendors
Serve as a key contributor to the discovery and development of antibody therapeutics for oncology and immune oncology for novel targets
Design and implement recombinant protein and bi- and multi-specific antibody discovery plans (immunogen design, assay development, screening, and functional characterization methods) and oversee the executions
Support biologic discovery through different platforms of protein and antibody discoveries
Oversee various target projects to execute protein production and antibody discovery/optimization in various platforms
Generate target over-expressing cell lines for antibody discovery work
Develop strategies to express, purify, and analyze proteins for novel tumor targets expressed in mammalian cells
Preferred
Extensive practical experience in developing and optimizing recombinant proteins, bi- and multi-specific antibody formats, and antibody developability across multiple parameters is preferred
Antibody drug discovery experience for immune oncology in biopharmaceutical industry is a plus
Ability to independently lead project strategy, plan, and execution on stringent timelines with quality to meet project goals is plus
Knowledge of the biologics drug discovery process and representation of the protein science function at project team meetings
Compliance with data management, laboratory notebook policy, and laboratory safety are plus
Benefits
Medical, dental and vision insurance for employee and dependents
FSA (Flexible Spending Account)
STD, LTD, Basic Life and AD&D Insurance, Supplemental Life
401(k) Plan
120 hours of Paid Time Off
5 sick days per year
11 public holidays
Employee Referral Bonus Program
Annual bonus program
New hire stock options
Company
Oxford BioTherapeutics
Oxford BioTherapeutics develops medicines for cancer and companion diagnostics for selected antibody programs.
11-50 employees
H1B Sponsorship
Oxford BioTherapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2020 (1)
Funding
Current Stage
Early StageTotal Funding
$33.22MKey Investors
Calculus CapitalOxford Finance LLCSilicon Valley Bank
2021-01-01Series Unknown
2018-08-03Series Unknown· $2.6M
2017-01-26Debt Financing· $10M
Leadership Team
Abderrahim Fandi, MD PhD
Chief Medical Officer
Joyce B.
Human Resources and Office Business Partner
Recent News
2025-12-15
MarketScreener
2025-12-10
Company data provided by crunchbase