Target RWE · 1 month ago
Head of Science
Research Triangle Park, North Carolina
Full-time
Onsite
Director/Executive
8+ years expNoviSci is a data science organization focused on developing software for real-world evidence and providing scientific consulting. The Head of Science will oversee scientific strategy, lead client work, and collaborate with various teams to ensure the effective translation of scientific methods into product requirements.
BiotechnologyHealth Care
Responsibilities
In collaboration with the President and other leaders, define the scientific vision across products and services
Translate strategy into an executable methods roadmap
Lead methods work, including estimator choice, diagnostics, validation, and reproducibility
Represent NoviSci with senior scientific leaders at biopharma, payers, regulators, and academic partners; lead and contribute to scientific publications and presentations
Collaborate with Product, Statistical Software Development, and Engineering to:
Define scientific requirements and acceptance criteria for features (estimands, estimators, diagnostics, simulation studies, data fitness checks)
Advise on high-level architecture (module requirements, data/metadata contracts, reproducibility/audit trails, performance considerations)
Co-design API specifications (inputs/outputs, parameterization, defaults, error handling, diagnostics objects) and review PRDs/tech specs for method fidelity
Provide reference implementations and simulation harnesses that teams use as ground truth for verification; help design CI checks and validation datasets
Establish documentation standards for methods notes, assumptions, and user-facing guidance
Serve as scientific lead/PI on select flagship engagements; architect designs for causal estimation of complex interventions under confounding, missingness, and dependent censoring; develop research protocols, review SAPs, code/figures, and narratives for validity and clarity
Define data fitness and cohort construction guardrails for claims/EHR/registries (including linkage/tokenization considerations) and ensure fit-for-purpose use
Act as senior scientific advisor to client teams (Epi/HEOR/Med Affairs); help mature their internal evidence pipelines and governance; evaluate platform fit and methods choices
Guide distributed/federated analyses and clean-room process; develop reusable scientific workflows
Supervise scientific team leads (principal investigators)
Hire, mentor, and train methodologists, scientific programmers, and research scientists; foster a rigorous, supportive, learning-oriented culture
Uplevel engineers and PMs on causal methods; uplevel scientists on software craft (versioning, testing, CI/CD, profiling)
Qualification
Required
PhD (or equivalent) in Epidemiology, Biostatistics, Statistics, or related field
8+ years post-doctoral experience spanning causal inference, statistical software, and real-world data (claims/EHR/registries); track record of leading complex studies to publication or regulatory use
Deep hands-on expertise with causal inference, including target trial emulation, MSMs/IPTW, IPCW, g-methods, longitudinal designs, and uncertainty quantification
Proven ability to translate scientific needs into product requirements, architecture trade-offs, and API designs in partnership with engineering (R and/or Python; package development; testing; performance profiling)
Executive-level client engagement; credible with senior scientific leaders across industry, regulators, and academia
Evidence of thought leadership (invited talks, committees, open-source, methods papers)
Preferred
Experience with CMS/Medicaid data governance and multi-source linkage/tokenization
Leadership in distributed data networks/federated analyses
Experience with protocol/report generators and figure/table QA pipelines (e.g., Quarto/R Markdown)
Comfort engaging on front-end reporting requirements for scientific outputs
Benefits
Comprehensive health, dental, and vision coverage for you and your family
401(k) with company match
Generous PTO and company holidays
Paid parental leave
Company
Target RWE
Target RWE is a provider of Biotechnology services.
51-200 employees
H1B Sponsorship
Target RWE has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (1)
Funding
Current Stage
Growth StageTotal Funding
unknown2025-01-07Acquired
Leadership Team
Edward Seguine
Chief Executive Officer
Michael W. Fried
Chief Medical Officer and Co-Founder
Recent News
2025-11-25
2025-11-07
2025-11-04
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