Apply on Employer Site

Glyphic Biotechnologies · 1 month ago

Scientist, Assay Development

Berkeley, CA

Full-time

Onsite

Mid, Senior Level

$90K/yr - $148K/yr

2+ years exp

Glyphic Biotechnologies is focused on creating a revolutionary protein sequencing platform. They are seeking an experienced Assay Development Scientist to design and perform experiments for sensitive and scalable single-molecule protein sequencing.

BiotechnologyHealth CareLife Science

Responsibilities

Plan, and execute experiments to improve the efficiency, accuracy, and scalability of Glyphic’s protein sequencing by expansion (ProSE) process

Propose, design, and test novel analytical approaches to optimize and build predictive understanding of critical components of the ProSE sequencing process including sample preparation, molecular expansion chemistry, and automation integration

Proactively identify, communicate, and help address experimental risks or resource gaps, such as reagent supply or instrument issues

Collaborate with scientists on the Assay Development team to ensure successful delivery of team goals and prioritize experiments accordingly

Collaborate with scientists in Chemistry, Bioinformatics, Process Development, and Engineering teams to assist and contribute to cross-functional projects

Collect, manage, and analyze data from molecular biology and protein sequencing experiments

Keep a detailed electronic lab notebook on Confluence

Communicate and present results in a timely manner

Qualification

Molecular biology expertiseAssay development experiencePCR-free sequencingData analysisBead-based automationMotivatedProactiveCommunication skillsDetail-orientedTeam collaboration

Required

BS/MS/PhD with 6+/4+/2+ (for Scientist II) or BS/MS/PhD with 4+/2+/0+ (for Scientist I) years of post-graduate experience in molecular biology, biochemistry, chemistry or related fields

Experience running and troubleshooting protocols for highly sensitive assays (PCR-free sequencing, single cell assays, NULISA)

Expertise and sound conceptual understanding of DNA-based assays, including ligation, hybridization capture, qPCR, and gel electrophoresis

Experience with and conceptual understanding of bead-based DNA or protein purification and QC methods such as gel extraction, Tapestation, Bioanalyzer, SeqStudio, and UV-vis absorbance measurements

Familiarity with chemical safety protocols for handling reagents such as strong acids and bases or working in anoxic and anhydrous environments (e.g., glove boxes)

Academic exposure to organic chemistry

Detail-oriented, organized, and able to keep accurate lab records

Strong written and verbal communication skills

Ability to work independently and as a team member

Motivated, enthusiastic, and proactive individual