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Flagship Pioneering · 1 month ago

(Senior) Scientist, ML/AI Antibody Design

Boston, MA USA

Full-time

Onsite

Mid, Senior Level

$115K/yr - $258K/yr

2+ years exp

FL108 Inc. is a privately held, early-stage biotechnology company focused on developing novel protein-based delivery modalities. The role involves pioneering the design of novel protein-based delivery modalities and collaborating with experimental teams to test and iterate on computational designs, leveraging expertise in computational protein design and AI/ML tooling.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Drive the AI/ML computational protein design

Engage with Pioneering Intelligence at Flagship to explore and implement novel ML models that benefit FL108 design principles

Advance both antibody engineering and de novo antibody design pipelines

Collaborate closely with the Fl108 experimental scientists to test and iterate on constructs

Engineer novel functionalities into protein scaffolds, leveraging structural modeling, rational design, and/or directed evolution

Be abreast of the computational protein design field to advise design and strategic directions for protein engineering, implementing the latest technologies where necessary

Contribute to strategic direction of the computational team at FL108, helping shape our design platform at the forefront of scientific innovation

Identify and lead external research relationships with academic and commercial partners

Report results to scientific team and Flagship Pioneering management

Qualification

Computational protein designML tools expertiseAntibody engineeringStructural biologyProtein biochemistryCommunication skillsTeam playerStrategic thinking

Required

Ph.D. (with 2+ yrs of industry research experience) in computational protein design, protein biochemistry, computational biophysics, computational biology, physics, or related field

Expertise in computational protein modeling and design, structural biology, and biophysics is required

Deep expertise with ML tools for computational protein design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapredis is required

Strategic thinker, able to shift seamlessly between rigorous scientific details and high-level context and implications

Instinctive team player with excellent communication skills and great attention to detail

Preferred

Experience with antibody and/or nanobody modeling and design is strongly preferred

Knowledge of critical wet-lab techniques used in protein engineering such as phage display, SPR, ITC, CD-spectroscopy is preferred

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

A broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)