Exelixis · 9 hours ago
Scientist III (In Vivo Studies)
Alameda, CA
Full-time
Onsite
Mid Level
$90K/yr - $128K/yr
3+ years expExelixis is a company focused on innovative therapies for cancer treatment, and they are seeking a Scientist III to support multidisciplinary research teams. The successful candidate will design and execute preclinical in vivo studies, integrating pharmacokinetics with pharmacodynamics and toxicology to assess drug exposure and efficacy.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Design and execute in vivo studies in both rat and mouse models and work with key stakeholders to provide interpretation around the pharmacokinetics, pharmacodynamics, efficacy, and toxicology of preclinical drug candidates
Coordinate with various functional groups, including PK, toxicology, pharmacology, formulation, and bioanalytical sciences, to ensure timely data delivery
Collaborate with various scientific functions within project teams to design in vivo studies to address hypotheses
Prepare and organize data for presentation using analysis and visualization software, present data and reports on project status at individual, group, and departmental research meetings
Maintain laboratory notebook in a complete, consistent, and concise manner following company intellectual property policies and practices
Adhere to good health and safety practices, comply with applicable EH&S rules, and participate in mandatory safety training programs
Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations
Maintain familiarity with current scientific literature relevant to the research experiments or program
Foster a science-driven, goal-oriented culture that values innovation, teamwork, agility, transparency, accountability, and empowerment
Qualification
Required
BS degree in a related discipline and a minimum of three years of related industry experience; or
Master's degree in a related discipline and a minimum of one year of experience; or
Equivalent combination of education and experience
Proficient with in vivo techniques, including animal handling (mouse and rat), different dosing routes (IV, IP, SC, PO, IM, etc.), blood collection techniques (tail vein, RO, cardiac puncture, etc.), and tissue collection/necropsy in rat and mouse
In-depth experience with animal tumor model development and execution; including, but not limited to syngeneic, xenograft, PDX and humanized mouse models is required
Expertise in cell culture with aseptic technique and scale-up for tumor implantation is required
Proven track record of good experimental design, in-depth data analysis, and interpretation based on strong scientific rationale
Strong knowledge and skills in working with rats and mice, as well as intimate knowledge of formulating in vivo study protocols, IACUC protocols, AAALAC guidelines, and vivarium techniques/best practices, are a must
Works independently; self-motivated, innovative, and proactive in identifying and troubleshooting issues
Has flexibility to accommodate a fast-paced work environment and deadlines and the ability to work under specific time constraints
Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in a team environment or independently
Advanced knowledge of MS Office, PDF, GraphPad, ELN notebook, and Studylog is required
Preferred
In-depth knowledge of pharmacokinetics and/or toxicology and/or pharmacology is preferred
Experience in pre-formulation for small molecules is a plus
Benefits
401k plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Sales-based incentive plan
Opportunity to purchase company stock
Receive long-term incentives
15 accrued vacation days in their first year
17 paid holidays including a company-wide winter shutdown in December
Up to 10 sick days throughout the calendar year
Company
Exelixis
Exelixis works is focused on discovering, developing and commercializing therapies for the treatment of cancer and other serious diseases.
1001-5000 employees
H1B Sponsorship
Exelixis has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (39)
2024 (25)
2023 (25)
2022 (28)
2021 (29)
2020 (15)
Funding
Current Stage
Public CompanyTotal Funding
$514MKey Investors
Deerfield
2015-07-23Post Ipo Equity· $135M
2012-02-16Post Ipo Equity· $65M
2010-06-03Post Ipo Debt· $160M
Leadership Team
Michael Morrissey
President and CEO
Christopher Senner
Executive Vice President and CFO
Recent News
2026-01-12
The Motley Fool
2026-01-09
Company data provided by crunchbase